Microphysiological System Solutions
Enhance the relevance of your research
Drug discovery endeavors require a deep understanding of biological systems and their response to potential therapeutics. That’s where microphysiological systems (MPS), also known as complex in vitro models (CIVM), play a pivotal role. They offer a more accurate representation of cellular biology that goes beyond traditional approaches, enabling researchers to understand disease mechanisms and find new treatments that translate into clinical response.
If you are working on your next 3D cell model project, and trying to select the right culture method, genetically modify your cells, automate your workflow, or analyze your samples and data, at Revvity we have microphysiological system solutions to partner with you with the purpose of reaching your goals. As regulatory agencies increasingly embrace New Approach Methodologies (NAMs), our MPS solutions support your transition towards more predictive, efficient and human-relevant alternatives to animal testing.
In vivo vs. complex in vitro models
Bioprinted models
Description
Allows researchers to form hydrogels with properties matching various tissue types and physiologically relevant matrix environments.
Benefits
- High reproducibility
- High throughput
- Suitable for HTS
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Organ-on-chip
Description
Microfluidic cell culture devices lined with living cells cultured under fluid flow.
Benefits
- Recapitulates human organ function and disease pathophysiology
- Assess the safety and efficacy of drug candidates in humans with greater precision
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Animal models
Description
Widely used models to track, monitor and visualize disease processes.
Benefits
- Evaluate effectiveness or toxicity of drug candidates
- Xenograft models (PDX) enable tumor growth monitoring
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Spheroids and organoids
Description
3D clusters of cells or mini-organs that are more physiologically relevant than traditional 2D cultures.
Benefits
- Mimic cell-to-cell interactions and the microenvironment
- Composed of different cell types of the original tissue
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Stem cell and iPSC-derived disease models
Description
Stem cells propagate indefinitely and can give rise to every other cell type in the body.
Benefits
- Models from healthy or diseased donors
- Study disease phenotypes at the cellular level
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For research use only. Not for use in diagnostic procedures.
Explore our solutions
Culture
When it comes to developing advanced physiological models, it’s critical to select the cell model with the right genomic context and biological function to recapitulate a healthy or diseased phenotype.
Achieving this level of accuracy requires tightly controlled culture conditions and reliable cell counting for cell seeding. Choosing a 2D or 3D cell culture method depends on the biological question, complexity of the desired model, and readout technology. Cells can be grown as monolayers, single spheroids in ultra-low attachment (ULA) plates, or cultured in hydrogels, offering a variety of options to enhance your research capabilities. Count on us to expertly scale up these methods, utilizing liquid handling techniques.
Featured products:
Microplates
Choosing the right microplate is a critical, often overlooked, part of an assay. The right microplate helps provides valuable data, whereas the wrong microplate can lead to missed or inaccurate data leading to missed project timelines and ultimately higher costs.
Fontus Workstations
With easy-to-use software, optimized deck access, verified protocols, and reformatting capabilities to simplify your workflows and improve turnaround times
Cell Counting & Image Cytometry Instruments
Revvity offers a leading portfolio of automated cell counters, image cytometry systems, and cell counting reagents and consumables. Together, they provide fast, accurate and efficient ways to assess cell health and viability.
Viral Vector Products
Viral vectors are the most efficient vehicles for gene delivery into a specific cell type or tissue for a wide array of research purposes.
Recombinant Proteins
Our portfolio includes over 2,000 bioactive human, mouse, and rat recombinant proteins developed in-house.
CRISPR Technologies
CRISPR-Cas9 genome engineering technologies hold great promise for understanding diseases and for the development of life saving treatments.
Treatment
In modern drug discovery, multiple screening methods play a vital role in identifying potential drug targets and eventual drug candidates. Traditionally, small molecule libraries were screened for compounds acting on a known molecule or for a desired biological effect. However, a drug candidate is only as good as its target.
To ensure the utmost precision, today’s drug discovery leverages gene editing or gene silencing methods such as CRISPR or siRNAs to identify suitable drug targets. Understanding the causal gene behind a phenotype or genes that contribute to a phenotype can significantly boost the confidence in a new drug candidate. Get ready to experience advancements in your research as we deliver convenience and efficiency.
Featured products:
Fontus Workstations
With easy-to-use software, optimized deck access, verified protocols, and reformatting capabilities to simplify your workflows and improve turnaround times
CRISPR Technologies
CRISPR-Cas9 genome engineering technologies hold great promise for understanding diseases and for the development of life saving treatments.
RNA Interference
Dharmacon™ siRNA, shRNA, and microRNA-based reagents, leading the field for nearly 30 years providing highly specific and efficient gene silencing.
Model Analysis
Selecting the right method for measuring the biological response of 3D cell models (whether organoids, spheroids, or organ-on-chip) depends on the specific research question and the characteristics of the model system in use.
Whether you’re repeatedly monitoring microtissue size or measuring sensitive detection of secreted proteins, each readout type poses unique challenges that can be overcome with the right tools. Our microplate readers, high-content analysis systems, and innovative reagents are complemented by specially designed microplates. Together, they shine a light on your samples, offering powerful insights to propel your research forward.
Featured products:
LabChip GX Touch Nucleic Acid Analyzer
Accurate sizing, quantification and quality control of DNA, RNA, and NGS libraries.
3D Cell Model Imaging and Analysis
Our high-content analysis systems and reagents provide sensitive solutions for 3D cell imaging, and our intuitive software platforms give you the tools to interrogate these complex models in detail
Microplate Readers
As many of you know, microplate readers are instruments used to detect biological, chemical, biochemical or physical events from samples in a microplate.
Immunoassays
Since their introduction in the 1950’s, immunoassays have been an integral part of research and drug discovery.
Luminescence Assays
Luciferase assays allow for the study of transcriptional gene expression, virus life cycles, and cell viability.
Nucleic Acid Purification
Revvity provides a unique and efficient method for isolating nucleic acids based on chemagic™ technology established over 25 years.
Cell Counting & Image Cytometry Instruments
Revvity offers a leading portfolio of automated cell counters, image cytometry systems, and cell counting reagents and consumables. Together, they provide fast, accurate and efficient ways to assess cell health and viability.
Multiomics and TotalSeq Reagents by BioLegend
Multiomics provides unparalleled protein and genetic analysis. Explore how our TotalSeq™ reagents can be integrated into your existing workflows and expand your capabilities.
Integrated Lab Automation
From cellular screening and imaging applications to high-throughput screening and genomics-based applications, custom explorer™ G3 integrated workstations
Data Analysis
Extracting insights from complex 3D datasets is no easy task. It requires the meticulous analysis of readouts and vast amounts of information (in context). Fortunately, we’ve got you covered.
With our scientific software and informatics solutions, you gain powerful tools to optimize 3D cell model imaging. Seamlessly aggregate, search, mine, and visualize critical data, converting it into actionable insights that drive your research forward. We are here to help you meet the challenges of data analysis head-on, so you can embark on a journey of ground-breaking discoveries.
Featured products:
Image Artist
Image Artist has powerful capabilities for processing, analyzing, storing, and sharing all your high-content screening and cell imaging data – so you can significantly cut your time to results.
Signals One
Make your innovations a reality with the first unified, cloud-native SaaS R&D platform that streamlines scientific complexity and promotes collaboration.
Services
Discover how our complex cell model screening services can accelerate your drug discovery and development goals. Our team leverage Revvity’s advanced imaging technologies and an extensive library of spheroids and primary immune cells to provide more biologically relevant data. This allows for better prediction of human responses to therapeutic interventions in immuno-oncology.
From assay design to high-throughput screening, we provide an end-to-end service that supports every phase of your drug development, with dedicated project management you can trust.
Featured services:
Advanced 3D cell culture models services
Our complex cell model screening services leverage Revvity’s advanced imaging technologies and an extensive library of spheroids and primary immune cells, providing more biologically relevant data.
Featured blogs
FAQs
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What are microphysiological systems (MPS)?
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What microphysiological systems are supported by Revvity's analysis solutions?
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What training and support do you provide during the transition to microphysiological system workflows?
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What automation capabilities do you offer for microphysiological system analysis?
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What are New Approach Methodologies (NAMs)?
