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Neuroscience Research Reagents

Over 55 million people worldwide are developing dementia and this number is expected to double by 2050. All the neurodegenerative disorders studies and associated pathways represent one of the biggest scientific challenges of today.

In this dedicated webpage you will discover how our large range of neuroscience assays can support your research into different neurodegenerative disorders, including:

  • Alzheimer’s disease
  • Parkinson’s disease
  • ALS and FTD
  • Huntington's disease
  • Rare diseases
  • Neuroinflammation
About neurodegenerative diseases

Neurodegenerative diseases occur when nerve cells in the brain or peripheral nervous system lose function over time and ultimately die:

  • Risk factors

Although treatments may help relieve some of the physical or mental symptoms associated with these diseases, there are currently no therapeutics to slow disease progression and no known cures. Revvity offers a wide panel of neuroscience immunoassays to help you in your research.

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626598-Icons-and-images-Neuroscience-webpage_Alzheimer’s-disease-icon
Alzheimer’s disease

Dive deeper into alzheimer’s disease.

Dive deeper into alzheimer’s disease.

Proteinopathies are correlated to neurodegenerative diseases leading to abnormal accumulation of misfolded, hyperphosphorylated, and aggregated proteins. These protein inclusions within neurons represent the primary hallmarks of major disorders such as Tau and amyloid-β proteins in Alzheimer’s Disease.

We provide a large selection of life science assays to quantify these biomarkers that represent the key signatures of neurodegenerative diseases.

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Parkinson’s disease

Boost you research on parkinson’s disease.

Boost you research on parkinson’s disease.

Dysfunction in protein homeostasis and/or the aggregation of certain proteins is the core of many neurodegenerative disorders. Protein inclusions within neurons represent the main indicator of diseases such as α-Synuclein in Parkinson’s Disease. One of the biggest challenges is to identify and detect key biomarkers of early-stage disease pathology and progression. Revvity develops assays to detect dysfunctions in neuronal mechanisms regulating protein degradation such as autophagy and mitophagy as well as key biomarkers in neuroinflammation, opening up new possibilities for the characterization of innovative treatments.

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ALS and FTD

Transcending ALS and FTD research

Transcending ALS and FTD research

Amyotrophic lateral sclerosis (ALS) affects the motor system and causes progressive degeneration of nerve cells in the spinal cord and brain. This leads to muscle weakness and loss of motor function, including the respiratory system. Frontotemporal dementia (FTP) consists in the degeneration of cortical neurons and basal ganglia leading to the loss of cognitive abilities.

Despite different symptoms, ALS and FTD share many similarities at the molecular level.

We offer a wide range of solutions and reagents to study ALS and FTD.

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Rare diseases

Revvity’s offer on rare diseases

Revvity’s offer on rare diseases

Dysfunction in protein homeostasis and/or the aggregation of certain proteins is the core issue for many neurogenerative diseases, including rare diseases such as Spinal Muscular Atrophy and Friedreich’s ataxia.

We have developed a variety of assays to monitor the biomarkers involved in theses disorders.

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Neuroinflammation

Get the best from your neuroinflammation research

Get the best from your neuroinflammation research

Improvements in neuroinflammation disorder understanding has led to better investigations of the pro and anti-inflammatory balance among transmitters that manage microglia and astrocyte cell behavior toward neurons. Revvity’s assays have been successfully used in this field for many years, demonstrating high relevance for the various requirements and formats of drug discovery.

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Guide
Alpha Protein-Protein Interaction Quick Start Guide
AlphaLISA protein assay immunoassay
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Application Note
Avoiding biotin interference in AlphaLISA assays
alphalisa assays biotin interferance
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Application Note
Characterizing Chemokine Receptor Inhibitors with AlphaLISA SureFire Ultra
surefire neutralizing antibody neutralizing antibodies biotherapeutics biotx
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Application Note
Comparison of EMT Biomarker Expression in 2D Monolayer and 3D Spheroid Cultures in a Prostate Cancer
3d culture spheroids alphalisa extracellular matrix proteins cancer
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Technical Note
Developing a high throughput AlphaLISA assay for screening activity of biologics produced by engineered probiotic microbes
Biologics Tenza AlphaLISA High Throughput Screening protein therapeutics
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Guide
ELISA to AlphaLISA Immunoassay Conversion Guide
ELISA conversion AlphaLISA long guide
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Application Note
High throughput assays to compare performance and stability of an engineered Fc Silent™ antibody to a therapeutic antibody
htrf alpha labchip performance stability fc silent
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Application Note
Protein extraction using the Omni Bead Ruptor Elite with detection of phosphorylation events using AlphaLISA no-wash assays
protein extraction immunoassays homogenizer
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Rapid, No-wash Measurement of Immune Checkpoint Molecules and Cytokines in Co-cultures of Immune Cells and Cancer Cell Lines
cytokine immune cells cancer cell lines biomarkers checkpoint application note
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Flyer
Reagent solutions for autoimmunity research.
alphalisa alpha htrf surefire autoimmunity flyer
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Screening for Inhibitors of PD-1 and PD-L1 Binding with AlphaLISA Technology
pd-1 pd-l1 binding interaction binding assay pdl-1 pd1
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Tracking Inflammasome Activity via Measuring IL-1β levels with AlphaLISA and HTRF
il1 beta inflammasome htrf alpha inflammation
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