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The Total RIPK1 kit is designed to monitor the expression level of cellular RIPK1, and can be used as a normalization assay for the Phospho-RIPK1 (Ser166) kit.
The Total-RIPK1 r assay monitors total RIPK1, and can be used as a normalization assay with the Phospho-RIPK1 (Ser166) kit. t is compatible with the buffers from the phospho-RIPK1 the same lysate can be used for analyses of both the phosphorylated and the total protein populations. Receptor-Interacting serine/threonine-Protein Kinase 1, also called RIP1 or RIP) is a iator of apoptotic and necrotic cell death, as well as for inflammatory pathways eam of TNFR1 and other receptors. utophosphorylation at Serine 166 is considered to be a biomarker of the initiation of RIPK3/MLKL-dependent necroptosis. roptosis ogrammed necrotic cell death pathway, also called "inflammatory cell death", s closely associated with pathologies including inflammatory and neurodegenerative diseases, as well as cancer. as therefore become an important drug target in the pharmaceutical industry. Therapeutic strategies consist in developing specific small-molecule kinase inhibitors, such as the well-known Necrostatin-1 and Necrostatin-1s.
|Assay Target Type
Oncology & Inflammation