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HTRF Human and Mouse Total RET Detection Kit, 500 Assay Points

The Total RET kit is designed to monitor the expression level of cellular RET, and can be used as a normalization assay for the Phospho-RET (pan) kit.

For research use only. Not for use in diagnostic procedures. All products to be used in accordance with applicable laws and regulations including without limitation, consumption & disposal requirements under European REACH regulations (EC 1907/2006).
Part Number: 64RETTPEY
Unit Size: 50,000 Assay Points
Part Number: 64RETTPEG
Unit Size:
Part Number: 64RETTPEH
Unit Size:
  • The Total-RET cellular assay monitors total RET (short and long isoforms), and can be used as a normalization assay with the Phospho-RET (pan) kit. This kit is compatible with the buffers from the Phospho-RET kit, so the same lysate can be used for analyses of both the phosphorylated and the total protein populations.

    The proto-oncogene RET (Rearranged during Transfection), also known as c-Ret, is a receptor tyrosine kinase primarily expressed as two isoforms of 1072 & 1114 amino acids. RET activation by Glial cell line-derived neurotrophic Family Ligands (GFL) leads to its dimerization and autophosphorylation on intracellular Tyrosine residues. RET is required for the development of the nervous system and several other tissues. RET alterations have been detected in numerous human cancers. The development of highly selective and potent RET kinase inhibitors is therefore of great interest to treat RET-altered cancers. Recently, RET has also been linked to neurodegeneration.

  • Application
    Protein Detection
    Assay Points
    500
    Assay Target Type
    Kit
    Assay Technology
    HTRF
    Automation Compatible
    Yes
    Brand
    HTRF
    Detection Method
    HTRF
    Experimental Type
    In vitro
    Quantity
    1
    Therapeutic Area
    Oncology & Inflammation

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Guide
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