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HTRF Human VHL Binding Kit, 500 Assay Points

The VHL binding assay is designed to screen and characterize compounds that specifically bind to the E3 ligase, VHL.

For research use only. Not for use in diagnostic procedures. All products to be used in accordance with applicable laws and regulations including without limitation, consumption & disposal requirements under European REACH regulations (EC 1907/2006).
Part Number: 64BDVHLPEH
Unit Size: 10,000 Assay Points
Part Number: 64BDVHLPEG
Unit Size: 500 Assay Points
  • A fast and easy way to identify new binders to VHL protein.

    VHL, also known as von Hippel-Lindau, is involved in many biological processes and is closely associated with the regulation of angiogenesis, cell growth, or cell survival.

    VHL is one of the most popular E3 ligases recruited by bifunctional Proteolysis-targeting chimeras (PROTACs) to induce ubiquitination and subsequent proteasomal degradation of a targeted protein.

    VHL interacts with several proteins to form the functional von Hippel-Lindau ubiquitination complex, in which VHL seems to act as a target recruitment subunit in the E3 ubiquitin ligase complex, and targets various proteins to proteolysis such as the hydroxylated hypoxia-inducible factor (HIF) under normoxic conditions.

    Therefore, identifying new PROTAC VHL ligands can improve selective proteasomal-dependent degradation of proteins of interest, involved in the onset of diseases such as cancers.

  • Automation Compatible
    Protein Detection
    Assay Points
    Assay Target Type
    Assay Technology
    Detection Method
    Experimental Type
    In vitro
    Therapeutic Area
    Oncology & Inflammation
    Unit Size
    500 Assay Points


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