Skip to main content

HTRF Human Total BRD2 Detection Kit, 500 Assay Points

This lysate is a component of the Total BRD2 kit. It may be used as a positive control for BRD2 protein quantification.

For research use only. Not for use in diagnostic procedures. All products to be used in accordance with applicable laws and regulations including without limitation, consumption & disposal requirements under European REACH regulations (EC 1907/2006).
Part Number: 64BRD2TPEG
Unit Size: 500 Assay Points
Part Number: 64BRD2TPEH
Unit Size: 10,000 Assay Points
  • BRD2 belongs to the bromodomain (BRD) Family II (BET). Like the other BRD family proteins, it binds to acetylated lysine and acts as a reader of the lysine acetylation state of proteins such as histones. It is a transcriptional regulator involved in many cell processes (embryogenesis, cycle regulation, development) through the E2F-RB pathway. BRD2 dysregulation is has been widely linked to many cancers, as it regulates the transcription of several oncogenes such as c-MYC ad Bcl-2.

    Thus, inhibition of the BRD2 function has become part of the strategy for cancer treatments. More recently, targeting BET family protein degradation, including BRD2 via PROTAC molecules, has emerged as a novel and promising therapeutic approach.

  • Application
    Protein Detection
    Assay Points
    500
    Assay Target Type
    Kit
    Assay Technology
    HTRF
    Automation Compatible
    Yes
    Brand
    HTRF
    Detection Method
    HTRF
    Experimental Type
    In vitro
    Therapeutic Area
    Oncology & Inflammation
    Unit Size
    500 Assay Points

Resources

1-1 of 1 Resources
Guide book
HTRF solutions, guide to major applications
HTRF, guide, application, autoimmunity, cardiology, assays