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HTRF Human CTLA4/CD80 biochemical Binding Kit, 500 Assay Points

This immune checkpoint assay is designed to identify human CTLA4/CD80 checkpoint inhibitors.

For research use only. Not for use in diagnostic procedures. All products to be used in accordance with applicable laws and regulations including without limitation, consumption & disposal requirements under European REACH regulations (EC 1907/2006).
Part Number: 64CTLA80PEG
Unit Size: 500 Assay Points
Part Number: 64CTLA80PEH
Unit Size: 10,000 Assay Points
  • CTLA4 (cytotoxic T-lymphocyte-associated protein 4), also known as CD152, is an inhibitor of the immune response expressed by T cells. CTLA4 and CD28 (stimulatory checkpoints) share the same ligands, namely CD80 (B7.1) and CD86 (B7.2), with CTLA4 displaying a greater affinity than CD28 for both, thus creating effective ligand binding competition. Although CTLA4 can be found on all T cells, it is mainly expressed on Treg (regulatory T cells), where it participates in their inhibition of the immune response.

  • Assay Points
    500
    Assay Technology
    HTRF
    Brand
    HTRF
    Quantity
    1
    Therapeutic Area
    Oncology & Inflammation
    Unit Size
    500 Assay Points

Resources

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Guide book
HTRF solutions, guide to major applications
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Flyer
Reagent solutions for autoimmunity research.
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