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AlphaLISA Human TREM2 Detection Kit, 100 Assay Points

This kit replaces AL3109. The AlphaLISA™ immunoassay kit for human TREM2 enables the quantitative determination of human TREM2 in buffer, cell culture media, serum, cell lysates and cell supernatants using a homogeneous AlphaLISA assay (no wash steps).

For research use only. Not for use in diagnostic procedures. All products to be used in accordance with applicable laws and regulations including without limitation, consumption and disposal requirements under European REACH regulations (EC 1907/2006).

Product Variants
Part number: AL3152HV
Unit Size: 100 Assay Points
List price: USD 1,159.00
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USD 1,159.00
USD 1,159.00 /each
Part number: AL3152C
Unit Size: 500 Assay Points
List price: USD 2,432.00
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USD 0.00
USD 2,432.00 /each
Part number: AL3152F
Unit Size: 5,000 Assay Points
List price: USD 16,260.00
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USD 0.00
USD 16,260.00 /each

Overview

TREM-2 is known as Triggering Receptor Expressed on Myeloid Cells 2. The TREM family of receptors regulates the activity of various cell types of the immune system, including neutrophils, monocyte/macrophages, microglia, and dendritic cells. Soluble TREM-2 has been detected in human cerebrospinal fluid (CSF), where it was found to be elevated in patients with multiple sclerosis and other inflammatory neurological conditions in comparison to patients without inflammatory neurologic disorders.

Formats
  • Our HV (100 assay point) kits allow you to run 100 wells in 96-well format, using a 100 µL reaction volume (10 µL of sample).
  • Our 500 assay point kit allows you to run 500 wells in 96-well or 384-well format, using a 50 µL reaction volume (5 µL of sample).
  • Our 5,000 assay point kit allows you to run 5,000 wells in 96-well or 384-well format, using a 50 µL reaction volume (5 µL of sample).
Feature:
  • No-wash steps, no separation steps
  • ELISA alternative technology
  • Sensitive detection
  • Broad sample compatibility
  • Small sample volume

AlphaLISA technology allows the detection of molecules of interest in a no-wash, highly sensitive, quantitative assay. In an AlphaLISA assay, a biotinylated anti-analyte antibody binds to the Streptavidin-coated Donor beads while another anti-analyte antibody is conjugated to AlphaLISA Acceptor beads. In the presence of the analyte, the beads come into close proximity. The excitation of the Donor beads causes the release of singlet oxygen molecules that triggers a cascade of energy transfer in the Acceptor beads, resulting in a sharp peak of light emission at 615 nm.

Specifications

Application
Protein Quantification
Automation Compatible
Yes
Brand
AlphaLISA
Detection Modality
Alpha
Dynamic Range
4 - 100,000 pg/mL  
Limit of Detection
4.3 pg/mL  
Limit of Quantification
13.8 pg/mL  
Product Group
Kit
Sample Volume
10 µL
Shipping Conditions
Shipped in Blue Ice
Target
TREM2
Target Class
Biomarkers
Target Species
Human
Technology
Alpha
Therapeutic Area
Central Nervous System
Unit Size
100 Assay Points

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Resources

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