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AlphaLISA SureFire Ultra Mouse Phospho-TDP-43 (Ser409/410) Detection Kit, 50,000 Assay Points

The AlphaLISA® SureFire® Ultra Mouse Phospho-TDP-43 (Ser409/410) assay is a sandwich immunoassay for quantitative detection of phospho-TDP-43 (Ser409/410) in cellular lysates using Alpha Technology.

For research use only. Not for use in diagnostic procedures. All products to be used in accordance with applicable laws and regulations including without limitation, consumption & disposal requirements under European REACH regulations (EC 1907/2006).
Part Number: ALSU-PTDP43-B50K
Unit Size: 50,000 Assay Points
Part Number: ALSU-PTDP43-B500
Unit Size: 500 Assay Points
Part Number: ALSU-PTDP43-B-HV
Unit Size: 100 Assay Points
Part Number: ALSU-PTDP43-B10K
Unit Size: 10,000 Assay Points
  • TAR DNA binding protein 43 (TDP-43) is a DNA and RNA-binding protein which plays a crucial role in RNA metabolism. Mainly located in the nucleus, TDP-43 shuttles between the nucleus and the cytoplasm. In pathological conditions, including stress or mutation, TDP-43 is mislocalized in the cytoplasm, which can be cleaved in C terminal fragments, thus leading to an accumulation of ubiquitinated and hyperphosphorylated toxic aggregates and then insoluble inclusion bodies. Aggregated TDP-43 has been identified as a hallmark of amyotrophic lateral sclerosis (ALS) and frontotemporal lobar dementia (FTLD), and more widely in several neurodegenerative diseases such as Alzheimer’s disease.

    The AlphaLISA SureFire Mouse Phospho-TDP-43 (Ser409/410) Detection Kit is a sandwich immunoassay for the quantitative detection of phospho-TDP-43 (Ser409/410) in cellular lysates, using Alpha Technology.

    Formats
    • The HV (high volume) kit contains reagents to run 100 wells in 96-well format, using a 60 μL reaction volume.
    • The 500-point kit contains enough reagents to run 500 wells in 384-well format, using a 20 μL reaction volume.
    • The 10,000-point kit contains enough reagents to run 10,000 wells in 384-well format, using a 20 μL reaction volume.
    • The 50,000-point kit contains enough reagents to run 50,000 wells in 384-well format, using a 20 μL reaction volume.
    AlphaLISA SureFire Ultra kits are compatible with
    • Cell and tissue lysates
    • Antibody modulators
    • Biotherapeutic antibodies
    Alpha SureFire kits can be used for
    • Cellular kinase assays
    • Receptor activation studies
    • Screening
  • Application
    Protein Detection
    Assay Target
    TDP-43
    Assay Technology
    Alpha
    Automation Compatible
    Yes
    Brand
    AlphaLISA SureFire Ultra
    Detection Method
    Alpha
    Experimental Type
    In vitro
    Target Species
    Mouse
    Therapeutic Area
    Neuroscience
    Unit Size
    50,000 Assay Points

Resources

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Application Note
Characterizing Chemokine Receptor Inhibitors with AlphaLISA SureFire Ultra
SureFire, neutralizing antibody, neutralizing antibodies, biotherapeutics, biotx