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The AlphaLISA® SureFire® Ultra™ Human Phospho-Cyclin D1 (Thr286) assay is a sandwich immunoassay for quantitative detection of phospho-cyclin D1 (Thr286) in cellular lysates using Alpha Technology.
Cyclin D1 is encoded by CCND1 and is a member of the highly conserved cyclin family, which includes Cyclin D2 and Cyclin D3. Cyclin family members are important regulators of cell cycle progression and act as mediatiors of growth factor dependent G1 to S phase progression by playing the role of allosteric regulators of CDK4/6. Cyclin D1 is an oncogene and is found to be overexpressed in many human cancers. Abnormal levels of Cyclin D1 result in dysregulated CDK4/6 activity and leads to tumorigenesis.
The AlphaLISA SureFire Human Phospho-Cyclin D1 (Thr286) Detection Kit is a sandwich immunoassay for the quantitative detection of phospho-Cyclin D1 (Thr286) in cellular lysates, using Alpha Technology.
Protein Analysis & Detection
|Assay Target Class
AlphaLISA SureFire Ultra