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High Content Imaging Instruments

From basic research to assay development and screening, Revvity's high-content imaging systems produce images of the highest quality so you can take your research further – and make discoveries faster. High-content screening (HCS) is a technique that combines fluorescence and brightfield microscopy with digital image analysis to identify and measure cellular components.

Both the Operetta CLS™ and Opera Phenix OptIQ™ are confocal spinning disk systems, providing gentle imaging with efficient background rejection, and are equipped with water immersion objectives for enhanced signal and improved z resolution.

For your most demanding applications, the Opera Phenix OptIQ system provides high-speed imaging from multiple cameras and simultaneous acquisition, especially for imaging in 3D. It's also available in a single camera configuration.

For research use only. Not for use in diagnostic procedures.

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Explore our high-content imaging products

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Opera Phenix OptIQ high-content screening system

Opera Phenix OptIQ™ high-content screening system for advanced 3D models and live-cell applications.

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Opera Phenix OptIQ™ high-content screening system for advanced 3D models and live-cell applications.

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Opera Phenix OptIQ high-content imaging system - single camera

The single camera Opera Phenix OptIQ™ System is configured for the research and budget of biopharma start-ups and smaller academic labs.

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The single camera Opera Phenix OptIQ™ System is configured for the research and budget of biopharma start-ups and smaller academic labs.

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Operetta CLS high content analysis system

Operetta CLS™ is a high throughput microplate imager for High-Content Analysis (HCA). It can acquire, analyze and manage fluorescence, brightfield and digital phase contrast images.

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Operetta CLS™ is a high throughput microplate imager for High-Content Analysis (HCA). It can acquire, analyze and manage fluorescence, brightfield and digital phase contrast images.

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Opera Phenix Plus high-content imaging system - single camera

The single camera Opera Phenix Plus System is configured for the research and budget of biopharma start-ups and smaller academic labs.

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The single camera Opera Phenix Plus System is configured for the research and budget of biopharma start-ups and smaller academic labs.

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Opera Phenix Plus high-content screening system

Opera Phenix Plus high-content screening system for demanding high-content applications.

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Opera Phenix Plus high-content screening system for demanding high-content applications.

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High-content screening system filters and lenses

Enable sensitive imaging on our cellular vivo imaging systems - at whatever resolution you desire. With our custom-designed optics, including optical filters, objectives and zoom lenses, you have the ideal view for any application.

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Enable sensitive imaging on our cellular vivo imaging systems - at whatever resolution you desire. With our custom-designed optics, including optical filters, objectives and zoom lenses, you have the ideal view for any application.

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Meet our users

Read how scientists around the globe are using our high-content screening products and services to advance their research in a variety of fields.

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Read how scientists around the globe are using our high-content screening products and services to advance their research in a variety of fields.

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Explore our high-content imaging technologies

Confocal imaging

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Spinning disk confocal microscopy offers several advantages over conventional optical microscopy, including widefield and laser scanning confocal microscopy.

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Water immersion objectives

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Proprietary automated water-immersion objectives with very high numerical aperture deliver and capture more photons and provide a higher resolution in XYZ than conventional objectives.

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Illumination

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Stability, brightness and spectral fit for excitation are key considerations for illumination sources in fluorescent imaging.

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sCMOS cameras

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The large-format sCMOS camera – one in Operetta CLS™ or up to four of them in the Opera Phenix - delivers low noise, wide dynamic range, and high resolution – perfect for sensitive and quantitative measurements at short exposure times.

Intelligent image acquisition

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More accurately target your object of interest for significantly reduced acquisition and analysis times with intelligent acquisition technology for HCS.

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Machine learning

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Machine learning techniques enable supervised and unsupervised feature selection and clustering of highly multi-parametric data sets.

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