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Opera Phenix Plus High-Content Imaging System - Single Camera

The single camera Opera Phenix Plus System is configured for the research and budget of biopharma start-ups and smaller academic labs.

A blend of innovation and affordability, this single-camera imager is engineered to help you accelerate your research and discoveries.

For details of multi-camera configurations, please visit the Opera Phenix Plus webpage.

For research use only. Not for use in diagnostic procedures.

Part #: HH14002001

Imaging Modality:

Brightfield, Confocal, Digital phase contrast, Fluorescence

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"Organoids from pediatric brain tumor imaged on the Opera Phenix Plus high-content screening system. "

Immortalized human podocytes imaged on the Opera Phenix Plus high-content screening system.

Arabidopsis cells imaged on the Opera Phenix high-content screening system.

HepG2 spheroids imaged on the Opera Phenix Plus high-content screening system.

Opera Phenix Plus High-Content Imaging System - Single Camera

revvity opera phenix plus image 700x700

Opera Phenix Plus High-Content Imaging System - Single Camera

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Pick a product variant

Brightfield, Confocal, Digital phase contrast, Fluorescence

Imaging Modality: Brightfield, Confocal, Digital phase contrast, Fluorescence

Part #: HH14002001

Request information

Product information

Overview

Unlock Deeper Insights with Opera Phenix Plus!

Discover More: High content imaging provides a greater depth of information than other approaches, allowing you to explore cellular processes in detail

Quantify in Detail: Analyze phenotypic changes at scale, from single cells to entire populations. High-content imaging empowers detailed quantification.

Enhance 3D Imaging: Water immersion objectives elevate 3D image quality, revealing intricate details within complex biological structures.

Boost Throughput: Add more cameras to increase speed and efficiency. High-content imaging accelerates your research pipeline.

Make meaningful discoveries faster with our advanced high-content imaging solutions.

Additional product information

Applications

Micro Physiological Systems (MPS)

Deepen understanding of 3D cell models with clearer images that reveal critical features and processes.

Functional genomic screening

Create genetic evidence with ease by phenotyping cellular response to thousands of gene manipulations in a single experiment.

Cell painting

Simplify multiparametric screening with out of the box reagents and analysis to reduce complexity (and create more time for you to focus on the science).

Drug sensitivity testing

Determine rational treatment selections regimens by rapidly characterizing ex vivo cellular function in response to drug treatment.

Features at a glance

microlens pinhole disk

Microlens-enhanced pinhole disk

Microlenses increase the excitation efficiency allowing for a bigger pinhole to pinhole distance thereby reducing out of focus light in confocal imaging.

automated water immersion objectives

Automated water-immersion objectives

Improve image quality and get better data by enhancing the signal and improving the z resolution while capturing more light.

machine learning

Machine learning

Easily create algorithms without being an image analysis expert using our PhenoLOGIC proprietary machine-learning technology.

intelligent image acquisition

Intelligent image acquisition

Image only the objects you are interested in, centered at high magnification, thereby reducing imaging time and data size.

powerfully simple analysis

Powerfully simple analysis

Harmony™ high-content imaging and analysis software can make you more productive faster with ready made templates and simple steps to a custom analysis

3d analysis

3D analysis

Explore your cell models by visualizing them in a 3D- and an XYZ-viewer and quantify volumetric and other 3D related phenotypic readouts.

multiple cameras

Upgradeable

Ability to add up to 3 further cameras to enable simultaneous image acquisition.

Opera Phenix Plus family – typical configurations

Opera Phenix Plus Single

The same sensitive and resolution as the rest of the Phenix family, with the ability to upgrade later with additional cameras.

Opera Phenix Plus Simultaneous

Higher speed, dual-camera system for multi-color, simultaneous confocal image acquisition and fast multiplexing.

Opera Phenix Plus FRET

With its five lasers and four-camera setup, it supports CFP/YFP FRET applications to map protein-protein interactions.

Opera Phenix Plus Screener

The ultimate in throughput and performance, it delivers four cameras and four higher powered lasers-supporting screening of large libraries.

		Single
System Options	Number of cameras	1
	Camera upgrade path	2 or 4 cameras
	Automated water immersion lenses	✔
	Transmitted light	✔
	Environmental control	✔
	On-board liquid handling	optional
	Robotics/Automation Compatible	✔
	Emission filters	8
Acquisition speed	2D/3D	+/+
Lasers	375/425 nm	-
	405 nm	✔
	488 nm	✔
	561 nm	✔
	640 nm	✔
Imaging modes	Synchrony optics for minimized simultaneous imaging cross talk	-
	Multi-color fluorescence imaging	✔
	Multi-color simultaneous confocal imaging	-
	3D imaging	✔
	Brightfield and digital phase contrast	✔
	Fluorescence widefield imaging	✔
	Ratiometric FRET*	+
	Fast frame rate imaging	✔

*CFP/YFP or spectrally similar pairs

Image aquisition and analysis simplified

Intuitive workflow: Harmony™ software offers an intuitive user interface that guides you from image acquisition to analysis and evaluation.
Templates for quick set-up: Templates allow you to set up acquisition channels and parameters efficiently.
Ready-made solutions: Choose from pre-built solutions for common image analysis tasks, simplifying your workflow.
Customizable building blocks: Create, configure, and customize your own high-content analysis applications using image analysis building blocks.
Advanced features: Harmony™ includes advanced analysis capabilities, such as texture and STAR morphology analysis, providing detailed descriptions of cellular morphology and robust differentiation of phenotypes.
Data management: The software automatically stores analysis results and metadata, including assay layout, instrument settings, and user-defined keywords and annotations.

Progress faster with verified solutions

Microplates for high-content imaging:
- Utilize PhenoPlate™ 384-well microplates designed for optimal performance in high-content imaging applications.
- Employ CellCarrier Spheroid ULA plates for imaging 3D models.
Automation and workstations:
- Improve throughput, productivity, and reduce variability and reagent costs by automating your Opera Phenix Plus system.
- Benefit from automated workflows using the explorer™ G3 workstations for cell painting, 3D cell culture, or phenotypic screening.
Efficient data management:
- Export results automatically into the Signals Image Artist™ platform that uses high performance computing and an industry standard object store to provide a scalable, multi-user solution for image analysis and management.
- Access, re-analyze, store, and share all your cell image data from Opera Phenix Plus and other high-content screening (HCS) systems.
Advanced analysis with Signals Research Suite:
- Perform screening data analysis and validation.
- Conduct QC analyses, calculate reliable normalization, multivariate hit stratification, dose-response curves, and drug response profiling.