Sample Sonication

Sonication involves the use of sound energy to agitate particles and molecules – singularly or as part of a network – in a fluid or liquid environment. If using frequencies above 20 kHz, this enters the category of ultrasonication. Within standard lab processes, sonication has become an indispensable and accessible tool for those looking for solutions for cell lysis. Sonication-based cell lysis is a durable and reliable technique, which tends to be deployed using either a 1:1 direct-to-sample probe or indirectly via a water bath delivery system. In terms of popular applications, sonication for cell lysis is performed by sonicators – or ultrasonic homogenizers – that can easily disrupt cell layers and cell membranes, making cellular content detectable by standard molecular techniques assessing DNA, RNA, protein, or small molecules.

Sonication and Ultrasonication for Reliable Cell Lysis

For many labs, sample preparation workflows tend to include some type of tissue or cell lysis technology to permit access to nucleic acids or protein, among other biological and chemical analytes, within a cell or tissue. Revvity offers sonicators and probes for sonication and cell disruption into a variety of downstream applications, including DNA- or chromatin-shearing and preparation of protein extracts. Consider a bead mill homogenizer to increase your tissue prep workflow. Alleviate bottlenecks and save by bundling

For research use only. Not for use in diagnostic procedures.

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sonicator ultrasonic homogenizer with generator probe

Sonicators - Ultrasonic homogenizers

Commonly called sonicators, ultrasonic homogenizers, utilize high-frequency ultrasonic waves to disrupt tissues and lyse cells via cavitation for researchers to access analytes such as nucleic acids and proteins within. The same principle allows applications such as DNA fragmentation and particle dispersion. In the lab, probe sonicators are well-used for small samples or volumes that require a smaller radius of exposure to high levels of energy from the sonicator probes selected compared to ultrasonic baths. Our line covers a comfortable range - from low volume to higher volumes, simple thumb switch control to easy programming interface, and for low wattage to higher wattage - for what would help your lab to get started or to scale.

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Sonicator probes & accessories

Sonicator accessories, including probes and ultrasonic tips, allow you to choose a size that is effective for your lab application and are easy-to-clean, interchangeable or replaceable, support a variety of lab applications such as tissue and cell disruption, DNA shearing, particle dispersion, and solution emulsification. A range of sonicator tip sizes and shape is available as standard probes, replacement tips, and microTips are available for our sonicators use in various cellular, chemical, and material applications. Stands and sound enclosures are also available.

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