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AequoZen Human Muscarinic M3 Cell Line, CHO-K1 Frozen Cells

Our frozen, irradiated AequoZen cells express a variety of GPCRs which all couple to a calcium response. Upon GPCR stimulation and subsequent calcium binding to the aequorin oxidation of coelenterazine leads to emission of light. No cell culture is required prior to testing, for these frozen cells.

This product contains living cells. Some AequoZen™ FroZen Cells may be restricted for sale in specified countries. Please inquire at your local sales office for more information.

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YEAREND15
Offer valid until 12/15. Terms and conditions apply.
Feature Specification
Application Drug Discovery & Development
G-Alpha Natural Receptor Gq/G11
Validation Calcium Luminescence

Our frozen, irradiated AequoZen cells express a variety of GPCRs which all couple to a calcium response. Upon GPCR stimulation and subsequent calcium binding to the aequorin oxidation of coelenterazine leads to emission of light. No cell culture is required prior to testing, for these frozen cells.

This product contains living cells. Some AequoZen™ FroZen Cells may be restricted for sale in specified countries. Please inquire at your local sales office for more information.

Click to copy promo code to clipboard.
SAVE 15% NOW on online orders. Use promo code below.
YEAREND15
Offer valid until 12/15. Terms and conditions apply.
Product Variant
Unit Size: 10 million cells
Part #:
ES-212-AF
List Price
USD 1,361.00

Overview

FroZen Cells validated for calcium testing: Muscarinic M3. Human Recombinant, in CHO-K1 host cell. We provide one vial of frozen cells (10 million cells/vial). Some of our Frozen cells may be restricted for sale in specified countries. Please inquire at your local sales office for more information. You are authorized to utilize these frozen cell preparations one time only. Any attempt to transfer, re-use, or propagate these cells is expressly unauthorized and a violation of the product terms and conditions of sale.

Features:

  • Pre-validated batches of ready-to-use cells for calcium testing
  • Optimized to alleviate biological variability
  • Step-by-Step protocols for culture-free functional testing on our validated cells
  • Affordable access to small aliquots of cells (minimum size: 10 million cells/vial)
  • Ready-to-use cells for Profiling, Pharmacology or Screening applications
  • Up-scaling and customized developments

The AequoScreen technology is a generic GPCR technology which can be used with Gs, Gi and Gq coupled GPCRs and calcium coupled ion channels. Following receptor stimulation, increases in intracellular calcium enable measurement of the resulting flash luminescence signal.

The frozen cells approach to functional testing consists in the dissociation of cell culture from testing. That means that we will culture the cells and freeze them with an optimized protocol to stop all replication. These cells are then stored in liquid nitrogen or simply in a -80°C freezer, thawed and used directly in a functional, cellular GPCR test with previously validated performance.

Specifications

Application
Drug Discovery & Development
Brand
AequoZen
G-Alpha Natural Receptor
Gq/G11
Host Cell Line
CHO-K1
Host Species
Human
One Unit Contains
1.0 Vials
Product Group
Cell Line
Receptor
Acetylcholine (Muscarinic)
Muscarinic
Second Messenger Release
Calcium flux
Shipping Conditions
Shipped in Dry Ice
Target Class
GPCR
Therapeutic Area
Cardiovascular
Gastrointestinal
Parasympathetic Nervous System
Unit Size
10 million cells
Validation
Calcium Luminescence

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