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IVISense Pan Cathepsin 750 Fluorescent Probe (ProSense)

Proteases perform a fundamental role in protein regulation. Altered activity of lysosomal cathepsins, a class of protease, can indicate many disease-related processes, such as those involved in cancer, inflammation, arthritis, cardiovascular and many others. The ability to detect and quantify normal as well as altered protease cathepsin activity in vivo allows the progress and severity of these disease states to be tracked and interrogated over time.

Revvity’s IVISense Pan Cathepsin fluorescent probes (ProSense®) are versatile pan-cathepsin-activatable NIR agents for imaging various disease-related events. These activatable probes are optically silent in their intact state and become highly fluorescent following protease-mediated cleavage and activation.

For research use only. Not for use in diagnostic procedures.

For research use only. Not for use in diagnostic procedures.
Part Number: NEV10003
Wave Length: 680 nm
Part Number: NEV10001EX
Wave Length: 750 nm
Part Number: NEV11171
Style: FAST
Wave Length: 750 nm
  • IVISense Pan Cathepsin 750 is in our family of “Smart” cathepsin probes, which become fluorescent only after enzymatic cleavage, keeping background down and allowing detection of activated protease. It also offers a secondary wavelength for IVISense Pan Cathepsin, to allow greater flexibility for multiplexing with probes of other excitation/emission wavelengths. 24h imaging at 750 nm.

  • Brand
    IVISense
    Fluorescent Agent Type
    Activatable
    Optical Imaging Classification
    Fluorescence Imaging
    Quantity in a Package Amount
    1.0 Units
    Shipping Conditions
    Shipped in Blue Ice
    Therapeutic Area
    Arthritis
    Atherosclerosis
    Inflammation
    Oncology/Cancer
    Unit Size
    1 Vial (10 doses)
    Wave Length
    750 nm

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