500 µCi quantities of Thyroxine, ([¹²⁵I]-T4), L-[¹²⁵I]-, are available for your research.

We offer radioligands and radiolabeled biomolecules to use as tracers, for radioimmunoassays (RIAs), for autoradiographic visualization, or for performing saturation and competition radioligand binding assays to determine receptor expression levels (B_max), dissociation constants (K_d), association and dissociation rates (k_on and k_off), and inhibitor constants (K_i) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radiolabeled compounds is fully characterized for pharmacological action and validated in binding assays.

Radiochemicals remain the most sensitive method for probing binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, Revvity has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.

References for NEX111:

1. Donald F. Sellitti, Yueh-Chu L. Tseng and Keith R. Latham, (1983), Nuclear Thyroid Hormone Receptors in C3H/HeN Mouse Mammary Glands and Spontaneous Tumors, Cancer Research 43 (3): 1030-1038.

References for NEX111H:

1. Sotelo-Rivera, I., Jaimes-Hoy, L., Cote-Vélez, A., Espinoza-Ayala, C., Charli, J.-L. and Joseph-Bravo, P. (2014), An Acute Injection of Corticosterone Increases Thyrotrophin-Releasing Hormone Expression in the Paraventricular Nucleus of the Hypothalamus but Interferes with the Rapid Hypothalamus Pituitary Thyroid Axis Response to Cold in Male Rats. J Neuroendocrinol, 26: 861–869.

References for NEX111X:

1. DuRant, S.E., Carter, A.W., Denver, R.J., Hepp, G.R., Hopkins, W.A., (2014), Are thyroid hormones mediators of incubation temperature-induced phenotypes in birds? Biology Letters, 10: 20130950.