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Thyroxine, ([125I]-T4), L-[125I]-, 500µCi (18.5MBq), Specific Activity: 5700µCi (210MBq)/µg

Thyroxine (T4) labeled with 125I. Thyroxine is a thyroid hormone that is responsible for regulation or metabolism. T4 detection by radioimmunoassay is a common test of thyroid disease. This product is offered at three specific activities. Specific activity indicates how much radioactivity there is per molecule of thyroxine. Several of our 125I-labeled ligands are offered at maximum specific activity (2200 Ci/mmol if one 125I labeling site is available, 4400 Ci/mmol if two labeling sites are available).

For research use only. Not for use in diagnostic procedures

Product Variants
Part number: NEX111X100UC
Unit Size: 100 µCi
List price: USD 1,622.00
Your price:
USD 0.00
USD 1,622.00 /each
Part number: NEX111X500UC
Unit Size: 500 µCi
List price: USD 4,761.00
Your price:
USD 4,761.00
USD 4,761.00 /each

Overview

500 µCi quantities of Thyroxine, ([125I]-T4), L-[125I]-, are available for your research.

We offer radioligands and radiolabeled biomolecules to use as tracers, for radioimmunoassays (RIAs), for autoradiographic visualization, or for performing saturation and competition radioligand binding assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radiolabeled compounds is fully characterized for pharmacological action and validated in binding assays.

Radiochemicals remain the most sensitive method for probing binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, Revvity has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.

References for NEX111:

  1. Donald F. Sellitti, Yueh-Chu L. Tseng and Keith R. Latham, (1983), Nuclear Thyroid Hormone Receptors in C3H/HeN Mouse Mammary Glands and Spontaneous Tumors, Cancer Research 43 (3): 1030-1038.

References for NEX111H:

  1. Sotelo-Rivera, I., Jaimes-Hoy, L., Cote-Vélez, A., Espinoza-Ayala, C., Charli, J.-L. and Joseph-Bravo, P. (2014), An Acute Injection of Corticosterone Increases Thyrotrophin-Releasing Hormone Expression in the Paraventricular Nucleus of the Hypothalamus but Interferes with the Rapid Hypothalamus Pituitary Thyroid Axis Response to Cold in Male Rats. J Neuroendocrinol, 26: 861–869.

References for NEX111X:

  1. DuRant, S.E., Carter, A.W., Denver, R.J., Hepp, G.R., Hopkins, W.A., (2014), Are thyroid hormones mediators of incubation temperature-induced phenotypes in birds? Biology Letters, 10: 20130950.

Specifications

Concentration
345 µCi/mL
Molecular Weight
776.9
Application
Drug Discovery & Development
Brand
NEN Radiochemicals
Detection Method
Radiometric
Fresh Lot Days
Third Monday of each month
Label Position
Nominally Labeled
One Unit Contains
500.0 µCi
Radionuclide
125I
Radioisotope
I-125
Receptor Type
Thyroid Hormone
Special Ordering Information
This is a radioactive product - shipping address must have a license to receive radioactive materials.
Therapeutic Area
Cardiovascular
Metabolic Disorders
Unit Size
500 µCi

Resources

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Calendar
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Guide
Iodine-125 handling precautions

This document contains general information designed to provide a basic understanding of radiation safety for Iodine-125. While we...

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