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Thymidine, [Methyl-3H]-, Specific Activity: 70-90Ci (2.59-3.33TBq)/mmol,>97%, 250µCi (9.25MBq)

Thymidine, tritiated on the methyl group. This product is supplied steri-packaged in an aqueous solution, and is typically used in DNA cell proliferation assays.

For research use only. Not for use in diagnostic procedures.

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Feature Specification
Concentration 1 mCi/mL
Label Position Specifically Labeled
Molecular Weight 242.2

Thymidine, tritiated on the methyl group. This product is supplied steri-packaged in an aqueous solution, and is typically used in DNA cell proliferation assays.

For research use only. Not for use in diagnostic procedures.

Click to copy promo code to clipboard.
SAVE 15% NOW on online orders. Use promo code below.
YEAREND15
Offer valid until 12/15. Terms and conditions apply.
Product Variants
Unit Size: 250 µCi
Part #:
NET027Z250UC
List Price
USD 713.25
Unit Size: 1 mCi
Part #:
NET027Z001MC
List Price
USD 1,304.00
Unit Size: 5 mCi
Part #:
NET027Z005MC
List Price
USD 3,144.00

Overview

250µCi quantity of [Methyl-3H]-Thymidine with specific activity of 70-90 Ci is available for your research. Application of [3H]Thymidine can be found in: carboxy-terminal PTH fragments stimulating incorporation in vascular endothelial cells, quantification of granulocyte-macrophage colony-stimulating factor (GM-CSF) hypersensitivity in juvenile myelomonocytic leukemia (JMML), influence of parasympathetic non-adrenergic, non-cholinergic mechanisms on uptake (rat) in response to mastication, measurement of dendritic cell induced T cell response by intracellular ATP levels and uptake in human immunology, etc.

Special Information: If aqueous solutions of thymidine are stored frozen (-20°C), care should be taken to protect the material from U.V. light during the thawing process to prevent possible dimerization.

When [methyl-3H]thymidine is incorporated into cellular DNA and undergoes radiolytic decomposition, [3H]5-hydroxymethyl-2''-deoxyuridine (HMdU) is formed.* The formation of HMdU through transmutation of [methyl-3H]thymidine occurs at the rate of B-decay, which is 0.017% per day. The transmutation product is not volatile.

*References

  • S. Apelgot and B. Ekert, J. Chem. Phys. 60, 505 (1963).
  • K. Fink, R. E. Cline, and R. M. Fink, Anal. Chem., 35, 389 (1963).
  • Specifications and Criteria for Biochemical Compounds, Third Edition (ISBN 0-309-01917-6), National Academy of Sciences - National Research Council, Washington, D.C. 1972.
  • G. W. Teebor, K. Frenkel, and M. S. Goldstein, Proc. Natl. Acad. Sci. USA 81, 318 (1984).
  • H. Tono, S.S. Cohen, J. Biol. Chem. 237, 1271 (1962).
  • M. Nemer, J. Biol. Chem. 237, 143 (1962).

Specifications

Concentration
1 mCi/mL
Molecular Weight
242.2
Application
Drug Discovery & Development
Brand
NEN Radiochemicals
Buffer/Solvent
Aqueous solution
Detection Modality
Radiometric
Label Position
Specifically Labeled
Packaging
NENSure vial
Radioisotope
3H
Shipping Conditions
Shipped Ambient
Special Ordering Information
This is a radioactive product - shipping address must have a license to receive radioactive materials.
Storage Conditions
5°C
Unit Size
250 µCi

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