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Sauvagine, [125I]-Tyr0], 10µCi

Sauvagine, labeled with 125I on the tyrosine 0 residue. Sauvagine is a neuropeptide that acts as an agonist at corticotropin-releasing factor receptors (CRF receptors) 1 and 2.

For research use only. Not for use in diagnostic procedures
Part Number: NEX306010UC
Unit Size: 10 µCi
Part Number: NEX306050UC
Unit Size: 50 µCi
  • 10 µCi Quantities of Sauvagine, [125I]-Tyr0] are available for your research.

    We offer radioligands and radiolabeled biomolecules to use as tracers, for radioimmunoassays (RIAs), for autoradiographic visualization, or for performing saturation and competition radioligand binding assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radiolabeled compounds is fully characterized for pharmacological action and validated in binding assays.

    Radiochemicals remain the most sensitive method for probing binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, Revvity has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.

    References for NEX306:

    1. Oakley, R.H., Olivares-Reyes, J.A., Hudson, C.C., Flores-Vega, F., Dautzenberg, F.M., Hauger, R.L. (2007), Carboxyl-terminal and intracellular loop sites for CRF1 receptor phosphorylation and beta-arrestin-2 recruitment: a mechanism regulating stress and anxiety responses. Am J Phsiol Regul Integr Comp Physiol., 293 (1): R209-222.
    2. Million, M., Grigoriadis, D.E., Sullivan, S., Crowe, P.D., McRoberts, J.A., Zhou, H., Saunders, P.R., Maillot, C., Mayer, E.A., Taché, Y. (2003), A novel water-soluble selective CRF1 receptor antagonist, NBI 35965, blunts stress-induced visceral hyperalgesia and colonic motor function in rats. Brain Res, 985 (1): 32-42.
  • Molecular Weight
    4778
    Application
    Drug Discovery & Development
    Brand
    NEN Radiochemicals
    Detection Method
    Radiometric
    Fresh Lot Days
    Fourth Monday of each month
    Label Position
    Nominally Labeled
    Radionuclide
    125I
    Radioisotope
    I-125
    Receptor Type
    Corticotropin-releasing factor
    Special Ordering Information
    This is a radioactive product - shipping address must have a license to receive radioactive materials.
    Therapeutic Area
    CNS & Neurologic
    Inflammation
    Unit Size
    10 µCi

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Iodine-125 handling precautions

This document contains general information designed to provide a basic understanding of radiation safety for Iodine-125. While we...