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Sauvagine, [125I]-Tyr0], 10µCi

Sauvagine, labeled with 125I on the tyrosine 0 residue. Sauvagine is a neuropeptide that acts as an agonist at corticotropin-releasing factor receptors (CRF receptors) 1 and 2.

For research use only. Not for use in diagnostic procedures.

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Feature Specification
Fresh Lot Days Fourth Monday of each month
Label Position Nominally Labeled
Molecular Weight 4778
Receptor Corticotropin-releasing factor

Sauvagine, labeled with 125I on the tyrosine 0 residue. Sauvagine is a neuropeptide that acts as an agonist at corticotropin-releasing factor receptors (CRF receptors) 1 and 2.

For research use only. Not for use in diagnostic procedures.

Click to copy promo code to clipboard.
SAVE 15% NOW on online orders. Use promo code below.
YEAREND15
Offer valid until 12/15. Terms and conditions apply.
Product Variants
Unit Size: 10 µCi
Part #:
NEX306010UC
List Price
USD 1,873.00
Unit Size: 50 µCi
Part #:
NEX306050UC
List Price
USD 7,254.00

Overview

10 µCi Quantities of Sauvagine, [125I]-Tyr0] are available for your research.

We offer radioligands and radiolabeled biomolecules to use as tracers, for radioimmunoassays (RIAs), for autoradiographic visualization, or for performing saturation and competition radioligand binding assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radiolabeled compounds is fully characterized for pharmacological action and validated in binding assays.

Radiochemicals remain the most sensitive method for probing binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, Revvity has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.

References for NEX306:

  1. Oakley, R.H., Olivares-Reyes, J.A., Hudson, C.C., Flores-Vega, F., Dautzenberg, F.M., Hauger, R.L. (2007), Carboxyl-terminal and intracellular loop sites for CRF1 receptor phosphorylation and beta-arrestin-2 recruitment: a mechanism regulating stress and anxiety responses. Am J Phsiol Regul Integr Comp Physiol., 293 (1): R209-222.
  2. Million, M., Grigoriadis, D.E., Sullivan, S., Crowe, P.D., McRoberts, J.A., Zhou, H., Saunders, P.R., Maillot, C., Mayer, E.A., Taché, Y. (2003), A novel water-soluble selective CRF1 receptor antagonist, NBI 35965, blunts stress-induced visceral hyperalgesia and colonic motor function in rats. Brain Res, 985 (1): 32-42.

Specifications

Molecular Weight
4778
Specific Activity
2200.0 Ci/mmol
Application
Drug Discovery & Development
Brand
NEN Radiochemicals
Buffer/Solvent
Acetonitrile : water (35:65), 0.05M mercaptoethanol, 0.2% TFA, and 0.2% BSA
Detection Modality
Radiometric
Fresh Lot Days
Fourth Monday of each month
Label Position
Nominally Labeled
Packaging
NENSure vial
Radioisotope
125I
Receptor
Corticotropin-releasing factor
Shipping Conditions
Shipped Ambient
Special Ordering Information
This is a radioactive product - shipping address must have a license to receive radioactive materials.
Storage Conditions
4°C
Therapeutic Area
CNS & Neurologic
Inflammation
Unit Size
10 µCi

Resources

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