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PEI PS SPA Imaging Beads, 50 mg

SPA imaging beads coated with polyethyleneimine (PEI) to decrease non-specific binding. These beads are commonly used in receptor binding assays.

For research use only. Not for use in diagnostic procedures.

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Feature Specification
Surface Treatment PEI

SPA imaging beads coated with polyethyleneimine (PEI) to decrease non-specific binding. These beads are commonly used in receptor binding assays.

For research use only. Not for use in diagnostic procedures.

Click to copy promo code to clipboard.
SAVE 15% NOW on online orders. Use promo code below.
YEAREND15
Offer valid until 12/15. Terms and conditions apply.
Product Variant
Unit Size: 50 mg
Part #:
RPNQ0297
List Price
USD 146.17

Overview

PEI polystyrene (PS) SPA imaging beads coated with polyethyleneimine (PEI) to decrease non-specific binding. These beads are commonly used in receptor binding assays.

SPA Imaging beads are microspheres containing scintillant which emit light in the red region of the visible spectrum. As a result, these beads are ideally suited to use with a CCD imager.

Two types of core SPA Imaging bead are available - yttrium oxide (YOx) and Polystyrene (PS). A number of biological coatings also exist for each core bead type to enable receptor binding, enzyme, molecular interaction and radioimmunoassays to be investigated.

Scintillation proximity assay (SPA) is a homogeneous and versatile technology for the rapid and sensitive assay of a wide range of biological processes, including applications using enzyme and receptor targets, radioimmunoassays, and molecular interactions. When 3H, 14C, 33P, and 125I radioisotopes decay, they release β-particles (or Auger electrons, in the case of 125I). The distance these particles travel through an aqueous solution is dependent on the energy of the particle. If a radioactive molecule is held in close enough proximity to a SPA Scintillation Bead or a SPA Imaging Bead, the decay particles stimulate the scintillant within the bead to emit light, which is then detected in a PMT-based scintillation counter or on a CCD-based imager, respectively. However, if the radioactive molecule does not associate with the SPA bead, the decay particles will not have sufficient energy to reach the bead and no light will be emitted. This discrimination of binding by proximity means that no physical separation of bound and free radiochemical is required.

Specifications

Application
Drug Discovery & Development
Automation Compatible
Yes
Bead Type or Material
Polystyrene (PS)
Brand
SPA Imaging Beads
Detection Modality
Radiometric
Format
Microplates
Tubes
Shipping Conditions
Shipped Ambient
Surface Treatment
PEI
Technology
Scintilation Proximity Assay
Unit Size
50 mg

Resources

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Guide
Optimization of SPA receptor binding assays

Scintillation proximity assay has been successfully applied to receptor binding assays

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