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Norepinephrine, Levo-[7-3H]-, 250µCi (9.25MBq)

Levo-Norepinephrine, tritiated at the 7 position. Norepinephrine binds and activates adrenergic receptors, and is cleared by the norepinehprine transporter (NET).

For research use only. Not for use in diagnostic procedures
Product Variants
Part number: NET377250UC
Unit Size: 250 µCi
List price: USD 2,675.00
Your price:
USD 2,675.00
USD 2,675.00 /each
Part number: NET377001MC
Unit Size: 1 mCi
List price: USD 7,254.00
Your price:
USD 0.00
USD 7,254.00 /each

Overview

250 µCi quantities of Norepinephrine, Levo-[7-3H]-, is available for your research. Norepinephrine (NA) is a neurotransmitter and hormone that increases heart rate and blood pressure, and is involved in the fight-or-flight response. It is widely used to treat low blood pressure.

We offer both agonist and antagonist radioligands for autoradiographic visualization or performing saturation and competition assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radioligands is fully characterized for pharmacological action and validated in receptor binding assays.

Radiolabeled ligands remain the most sensitive method for probing receptor binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, Revvity has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.

References for NET377:

  1. Jeannotte, A. M. and Sidhu, A. (2007), Regulation of the norepinephrine transporter by α-synuclein-mediated interactions with microtubules. European Journal of Neuroscience, 26: 1509–1520.
  2. Wersinger, C., Jeannotte, A. and Sidhu, A. (2006), Attenuation of the norepinephrine transporter activity and trafficking via interactions with α-synuclein. European Journal of Neuroscience, 24: 3141–3152.

Specifications

Molecular Weight
169.2
Application
Drug Discovery & Development
Brand
NEN Radiochemicals
Detection Method
Radiometric
Label Position
Nominally Labeled
Radionuclide
3H
Radioisotope
H-3
Shipping Conditions
Shipped in Dry Ice
Special Ordering Information
This is a radioactive product - shipping address must have a license to receive radioactive materials.
Therapeutic Area
CNS & Neurologic
Unit Size
250 µCi

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