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MIP-1α (human, recombinant), [125I], 5µCi

Human recombinant macrophage inflammatory protein 1-alpha (MIP-1α; CCL3), labeled with 125I. MIP-1α is a cytokine involved in acute inflammation, and binds C-C chemokine receptors CCR1, CCR4, and CCR5.

For research use only. Not for use in diagnostic procedures.

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YEAREND15
Offer valid until 12/15. Terms and conditions apply.
Feature Specification
Fresh Lot Days Second Monday of each month
Label Position Nominally Labeled
Molecular Weight ~8000
Receptor Chemokine

Human recombinant macrophage inflammatory protein 1-alpha (MIP-1α; CCL3), labeled with 125I. MIP-1α is a cytokine involved in acute inflammation, and binds C-C chemokine receptors CCR1, CCR4, and CCR5.

For research use only. Not for use in diagnostic procedures.

Click to copy promo code to clipboard.
SAVE 15% NOW on online orders. Use promo code below.
YEAREND15
Offer valid until 12/15. Terms and conditions apply.
Product Variants
Unit Size: 5 µCi
Part #:
NEX298005UC
List Price
USD 1,321.00
Unit Size: 25 µCi
Part #:
NEX298025UC
List Price
USD 5,416.00

Overview

5 µCi Quantities of MIP-1α (human, recombinant) are available for your research.

We offer radioligands and radiolabeled biomolecules to use as tracers, for radioimmunoassays (RIAs), for autoradiographic visualization, or for performing saturation and competition radioligand binding assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radiolabeled compounds is fully characterized for pharmacological action and validated in binding assays.

Radiochemicals remain the most sensitive method for probing binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, Revvity has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.

References for NEX298:

  1. Cavallaro, C.L., Briceno, S., Chen, J., Cvijic, M.E., Davies, P., Hynes, J. Jr, Liu, R.Q., Mandlekar, S., Rose, A.V., Tebben, A.J., Van Kirk, K., Watson, A., Wu, H., Yang, G., Carter, P.H. (2012), Discovery and lead optimization of a novel series of CC chemokine receptor 1 (CCR1)-selective piperidine antagonists via parallel synthesis. J Med Chem, 55 (22): 9643-9653.

Specifications

Molecular Weight
~8000
Specific Activity
2200.0 Ci/mmol
Application
Drug Discovery & Development
Brand
NEN Radiochemicals
Buffer/Solvent
Lyophilized
Detection Modality
Radiometric
Fresh Lot Days
Second Monday of each month
Host Species
Human
Label Position
Nominally Labeled
Packaging
NENSure vial
Radioisotope
125I
Receptor
Chemokine
Shipping Conditions
Shipped Ambient
Special Ordering Information
This is a radioactive product - shipping address must have a license to receive radioactive materials.
Storage Conditions
4°C
Therapeutic Area
Inflammation
Unit Size
5 µCi

Resources

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Product Info
Calendar: NEN® Radiochemicals 2024 Fresh Lot
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Guide
Iodine-125 handling precautions

This document contains general information designed to provide a basic understanding of radiation safety for Iodine-125. While we...

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NENSure: The safest packaging for radiochemicals
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