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MIP-1α (human, recombinant), [125I], 5µCi

Human recombinant macrophage inflammatory protein 1-alpha (MIP-1α; CCL3), labeled with 125I. MIP-1α is a cytokine involved in acute inflammation, and binds C-C chemokine receptors CCR1, CCR4, and CCR5.

For research use only. Not for use in diagnostic procedures

Product Variants
Part number: NEX298005UC
Unit Size: 5 µCi
List price: USD 1,321.00
Your price:
USD 1,321.00
USD 1,321.00 /each
Part number: NEX298025UC
Unit Size: 25 µCi
List price: USD 5,416.00
Your price:
USD 0.00
USD 5,416.00 /each

Overview

5 µCi Quantities of MIP-1α (human, recombinant) are available for your research.

We offer radioligands and radiolabeled biomolecules to use as tracers, for radioimmunoassays (RIAs), for autoradiographic visualization, or for performing saturation and competition radioligand binding assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radiolabeled compounds is fully characterized for pharmacological action and validated in binding assays.

Radiochemicals remain the most sensitive method for probing binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, Revvity has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.

References for NEX298:

  1. Cavallaro, C.L., Briceno, S., Chen, J., Cvijic, M.E., Davies, P., Hynes, J. Jr, Liu, R.Q., Mandlekar, S., Rose, A.V., Tebben, A.J., Van Kirk, K., Watson, A., Wu, H., Yang, G., Carter, P.H. (2012), Discovery and lead optimization of a novel series of CC chemokine receptor 1 (CCR1)-selective piperidine antagonists via parallel synthesis. J Med Chem, 55 (22): 9643-9653.

Specifications

Application
Drug Discovery & Development
Brand
NEN Radiochemicals
Detection Method
Radiometric
Fresh Lot Days
Second Monday of each month
Label Position
Nominally Labeled
Radionuclide
125I
Radioisotope
I-125
Receptor Type
Chemokine
Species
Human
Shipping Conditions
Shipped Ambient
Special Ordering Information
This is a radioactive product - shipping address must have a license to receive radioactive materials.
Therapeutic Area
Inflammation
Unit Size
5 µCi

Resources

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Calendar
2024 Fresh Lot Calendar
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Guide
Iodine-125 handling precautions

This document contains general information designed to provide a basic understanding of radiation safety for Iodine-125. While we...

SDS, COAs, Manuals and more Illuminator

SDS, COAs, Manuals and more

Are you looking for technical documents for this product. We have housed them in a dedicated section., click on the links below to explore.

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