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Insulin-like Growth Factor-I (human, recombinant), 5µCi

Insulin-like growth factor 1 (IGF-1), labeled with 125I. IGF-1 acts as an agonist at the IGF-1 receptor, a receptor tyrosine kinase, that plays a role in growth, cancer, and aging. IGF-1 also binds the insulin receptor (IR), another receptor tyrosine kinase involved in glucose homeostasis, diabetes, and cancer.

For research use only. Not for use in diagnostic procedures
Part Number: NEX241005UC
Unit Size: 5 µCi
Part Number: NEX241025UC
Unit Size: 25 µCi
  • 5 µCi Quantities of Insulin-like Growth Factor-I (human, recombinant) are available for your research.

    We offer radioligands and radiolabeled biomolecules to use as tracers, for radioimmunoassays (RIAs), for autoradiographic visualization, or for performing saturation and competition radioligand binding assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radiolabeled compounds is fully characterized for pharmacological action and validated in binding assays.

    Radiochemicals remain the most sensitive method for probing binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, Revvity has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.

    References for NEX241:

    1. Takahashi, T., Y. Kobayashi, S. Haga, Y. Ohtani, K. Sato, Y. Obara, A. Hagino, S. G. Roh, and K. Katoh. (2012), A high-protein diet induces dissociation between plasma concentrations of growth hormone and ghrelin in wethers. J. Anim. Sci. 90: 4807-4813.
    2. Runnels, H.A., Arbuckle, J.A., Bailey, K.S. et al. (2010), Human monoclonal antibodies to the insulin-like growth factor 1 receptor inhibit receptor activation and tumor growth in preclinical studies, Adv Therapy, 27: 458-475.
  • Molecular Weight
    7773
    Application
    Drug Discovery & Development
    Brand
    NEN Radiochemicals
    Detection Method
    Radiometric
    Fresh Lot Days
    Third Monday of each month
    Label Position
    Nominally Labeled
    Radionuclide
    125I
    Radioisotope
    I-125
    Receptor Type
    Insulin-like Growth Factor
    Shipping Conditions
    Shipped Ambient
    Special Ordering Information
    This is a radioactive product - shipping address must have a license to receive radioactive materials.
    Therapeutic Area
    Cancer
    Diabetes
    Unit Size
    5 µCi

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Guide
Iodine-125 handling precautions

This document contains general information designed to provide a basic understanding of radiation safety for Iodine-125. While we...