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Histamine Dihydrochloride, [Ring, Methylenes-3H(N)]-, 250µCi (9.25MBq)

Histamine dihydrochloride, tritiated on the ring and methylene groups. Histamine is an endogenous agonist of histamine receptors.

For research use only. Not for use in diagnostic procedures.

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Feature Specification
Concentration 1 mCi/ml
Label Position Nominally Labeled
Molecular Weight 184
Receptor Histamine

Histamine dihydrochloride, tritiated on the ring and methylene groups. Histamine is an endogenous agonist of histamine receptors.

For research use only. Not for use in diagnostic procedures.

Click to copy promo code to clipboard.
SAVE 15% NOW on online orders. Use promo code below.
YEAREND15
Offer valid until 12/15. Terms and conditions apply.
Product Variant
Unit Size: 250 µCi
Part #:
NET732250UC
List Price
USD 3,548.00

Overview

Histamine is the endogenous ligand that binds and activates histamine receptors. These receptors are a class of GPCRs involved in ileum contraction, itching, vasodiluation, bronchoconstriction, and smooth muscle relaxation. Histamine receptors are potential drug targets for asthma, allergy, and cognitive disorders including sleep disorders, Tourette syndrome, Parkinson disease, ADHD, and drug addiction.

We offer both agonist and antagonist radioligands for autoradiographic visualization or performing saturation and competition assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radioligands is fully characterized for pharmacological action and validated in receptor binding assays.

Radiolabeled ligands remain the most sensitive method for probing receptor binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust.

Specifications

Concentration
1 mCi/ml
Molecular Weight
184
Application
Drug Discovery & Development
Brand
NEN Radiochemicals
Buffer/Solvent
Ethanol : 0.01N hydrochloric acid (1:1)
Detection Modality
Radiometric
Label Position
Nominally Labeled
Packaging
NENSure vial
Radioisotope
3H
Receptor
Histamine
Shipping Conditions
Shipped Ambient
Special Ordering Information
This is a radioactive product - shipping address must have a license to receive radioactive materials.
Storage Conditions
-20°C
Therapeutic Area
Gastrointestinal
Inflammation
Metabolic Disorders
Pain
Unit Size
250 µCi

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