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Cholecystokinin Octapeptide, [125I]-, Bolton-Hunter Labeled, 10µCi

Cholecystokinin Octapeptide (CCK-8), labeled with 125I. Cholecystokinin is a neuropeptide that exists in several forms, identified by the number of amino acids in the peptide sequence. CCK8 contains 8 amino acids. The sulphated version of cholecystokinin can bind both Cholecystokinin A and Cholecystokinin B receptors. These receptors are involved in anxiety, feeding, and locomotion and are potential drug targets for depression and satiety.

For research use only. Not for use in diagnostic procedures
Part Number: NEX203010UC
Unit Size: 10 µCi
Part Number: NEX203050UC
Unit Size: 50 µCi
  • 10 µCiQuantities of Cholecystokinin Octapeptide, [125I]-, Bolton-Hunter Labeledare available for your research.

    We offer radioligands and radiolabeled biomolecules to use as tracers, for radioimmunoassays (RIAs), for autoradiographic visualization, or for performing saturation and competition radioligand binding assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radiolabeled compounds is fully characterized for pharmacological action and validated in binding assays.

    Radiochemicals remain the most sensitive method for probing binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, Revvity has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.

    References for NEX203:

    1. Kopin, A.S., McBride, E.W., Chen, C., Freidinger, R.M., Chen, D., Zhao, C.M., Beinborn, M. (2003), Identification of a series of CCK-2 receptor nonpeptide agonists: sensitivity to stereochemistry and a receptor point mutation. PNAS, 100 (9): 5525-5530.
    2. Kopin, A.S., Lee, Y.M., McBride, E.W., Miller, L.J., Lu, M., Lin, H.Y., Kolakowski, L.F. Jr, Beinborn, M. (1992), Expression cloning and characterization of the canine parietal cell gastrin receptor. PNAS, 89 (8): 3605-3609.
  • Application
    Drug Discovery & Development
    NEN Radiochemicals
    Detection Method
    Fresh Lot Days
    First Monday of each month
    Label Position
    Nominally Labeled
    Receptor Type
    Shipping Conditions
    Shipped in Dry Ice
    Special Ordering Information
    This is a radioactive product - shipping address must have a license to receive radioactive materials.
    Therapeutic Area
    CNS & Neurologic
    Unit Size
    10 µCi


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