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iodo-(±)-Cyanopindolol, [125I], 100µCi (3.7MBq)

Iodo-(±)-cyanopindolol, labeled with 125I. Cyanopindolol acts as an antagonist at β1 adrenergic receptors and serotonin 5-HT1A receptors.

For research use only. Not for use in diagnostic procedures

Product Variants
Part number: NEX174100UC
Unit Size: 100 µCi
List price: USD 3,227.00
Your price:
USD 3,227.00
USD 3,227.00 /each
Part number: NEX174500UC
Unit Size: 500 µCi
List price: USD 16,490.00
Your price:
USD 0.00
USD 16,490.00 /each

Overview

100 µCi Quantities of iodo-(±)-Cyanopindolol, [125I], are available for your research.

We offer radioligands and radiolabeled biomolecules to use as tracers, for radioimmunoassays (RIAs), for autoradiographic visualization, or for performing saturation and competition radioligand binding assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radiolabeled compounds is fully characterized for pharmacological action and validated in binding assays.

Radiochemicals remain the most sensitive method for probing binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, Revvity has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.

References for NEX174:

  1. Flügge, G., Ahrens, O. & Fuchs, E. (1997) β-Adrenoceptors in the Tree Shrew Brain. II. Time-Dependent Effects of Chronic Psychosocial Stress on [125I]Iodocyanopindolol Binding Sites, Cell Mol Neurobiol 17: 417-432.
  2. Pei, G., Samama, P., Lohse, M., Wang, M., Codina, J., Lefkowitz, R.J. (1994), A constitutively active mutant beta 2-adrenergic receptor is constitutively desensitized and phosphorylated, PNAS, 91 (7): 2699-2702.

Specifications

Molecular Weight
411
Application
Drug Discovery & Development
Brand
NEN Radiochemicals
Detection Method
Radiometric
Fresh Lot Days
First Monday of each month
Label Position
Nominally Labeled
Radionuclide
125I
Radioisotope
I-125
Receptor Type
Adrenoceptors
Special Ordering Information
This is a radioactive product - shipping address must have a license to receive radioactive materials.
Therapeutic Area
Cardiovascular
CNS & Neurologic
Metabolic Disorders
Unit Size
100 µCi

Resources

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Calendar
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Guide
Iodine-125 handling precautions

This document contains general information designed to provide a basic understanding of radiation safety for Iodine-125. While we...

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SDS, COAs, Manuals and more

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