Newborn Sequencing Research

With the latest advancements in next generation sequencing (NGS), we are experiencing rapid acceleration in genetic disease research and neonatal research. While NGS maintains the power to detect genetic variants responsible for many diseases, these technologies have been inaccessible for many laboratories.

Through our decades of experience in rare disease technologies, Revvity has developed an end-to-end neonatal sequencing workflow to suit your needs. Our configurable, holistic workflow – from the DNA extraction of dried blood spot samples, library preparation, automated liquid handling, sequencing, to final data analysis – is built to bring newborn genome sequencing into the hands of more laboratories. One end-to-end solution, all from one supplier who specializes in newborn DNA analysis.

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For research use only. Not for use in diagnostic procedures.

Benefits for your laboratory

Targeted sequencing vs. WGS

While our workflow supports both WGS and targeted sequencing, we recommend targeted as the optimal starting point. This approach has fewer data security concerns, storage requirements and brings added simplicity to data assessment. Reach out to us to determine which method is best for you.

Newborn sequencing lab services

As an alternative to adopting our solution, you may choose to consider outsourcing the workflow through Revvity Omics – our global network of laboratories. Comprised of the same instrumentation and trusted internationally, see how you can leverage our genomic technologies with Revvity Omics today.

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Exploring NGS for newborns

See what’s possible with Revvity’s NGS for neonatal research workflow.

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Workflow steps

From sample to final result, we cover the entire sequencing process.

Sample collection

226 Sample Collection Device

A dried blood spot card that delivers reliable and homogenous analytical results from across the dried sample area. Enables simplified sample collection and delivery.

Revvity 226 Spot Saver RUO Card

Laboratory LIMS

Revvity Genomics LIMS

Our cloud-based, platform solution is primed for secure data management and LIS integration. The solution operates on ISO27001 certified cloud technology while the application is designed to comply with GDPR and HIPAA requirements.

Revvity Genomics Software

Sample extraction

Multiple Options

Revvity Puncher Instruments

Simplified and robust options for your DBS (dried blood spot) punching needs. Equipped with semi-automatic punching capabilities and a changeable head, punch DBS samples into microtitration plates with ease.

Chemagen 360 Instrument & Kits

Chemagen’s well-established magnetic bead-based technology brings reliability to sample extraction. Chemagen is optimized for extracting high-quality and high-yield genomic DNA from dried blood spot samples, making it the perfect choice for newborn sequencing research.

chemagic 360 Instrument

Sample QC and quantification

Multiple Options

With a host of solutions, we offer several reliable systems that are designed to quantify and assess the quality of your DNA samples. Get fast, high-throughput QC analysis of your samples.

Library preparation

NEXTflex^® Kits

Offers robust genome coverage to identify variants in 390+ genes. Targeted regions are designed for comprehensive research of early onset disorders. Library prep is also Illumina^® and Element Biosciences compatible.

NEXTFLEX Neo NGS RUO Panel 1

Library preparation automation

Multiple options

With a portfolio of automated liquid handling solutions, Revvity offers flexibility and throughput to meet your needs. Our instrumentation is designed to minimize cross-contamination and user error.

Library QC and quantification

Multiple options

With a host of solutions to serve your unique needs, Revvity delivers fast, high-throughput QC analysis of NGS libraries. Enables a simplified approach to DNA fragment analysis, including NGS library QC.

Sequencing

Element Biosciences AVITI^™ and Illumina^®

Compatible library with AVITI sequencers and Illumina platforms. With unparalleled performance, the cost-effective AVITI system reimagines sequencing with your needs in mind. Built for fast turnaround time, the AVITI benchtop sequencer can complete a 2x150 run with indexing, generating up to 600 GB of data and 2 billion reads.

Revvity Genomics Analysis_OnScreen-160x160

Primary and secondary analysis

Revvity Genomics Analyze

Built to offer a seamless fit to your analytical needs for sequencing data, our software offers alignment and variant calling to your laboratory. Software operates on the same closed & secure platform as our LIMS solution and is compatible with both Element Biosciences and Illumina sequencers.

Revvity Genomics Software

Tertiary analysis and reporting

Revvity Genomics Interpret

Our software enables easy result interpretation for your research needs. Preview, add comments and select your report delivery method, all in-app. A cloud-based application, users can login from anywhere for easy access reporting. Software operates on the same closed & secure platform as our LIMS solution.