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Cell Line Engineering

Your edit. Our expertise 

Working with you, we can support your research with our stellar cell engineering services and provide the tools you need to understand and interrogate the biology of disease.

Specialized cell line engineering services that are backed by an extensive portfolio of gene-editing licences and expertise across hundreds of cell lines to ensure the right edited cell line solution is achieved. Broad capabilities, powered by Dharmacon™ reagents, with a specific focus on complex edits and challenging cell types include:

  • Multigene targeting knockouts
  • Large knock-ins
  • iPSC
  • Primary T-cell
  • Polyploid cancer lines 
Step 1 – Project design

Our experts review your project requirements and provide consultation before onboarding. Choose from our catalogue of parental cell lines or provide your own including iPSCs, primary T-cells, and polyploidy cell lines. 

Our experts review your project requirements and provide consultation before onboarding. Choose from our catalogue of parental cell lines or provide your own including iPSCs, primary T-cells, and polyploidy cell lines. 

Step 2 – Project engineering

We optimize reagents and transfection protocols, then use automation and machine learning for single-cell dilution. Clones are screened with sequencing to ensure optimal clones are banked and delivered. 

We optimize reagents and transfection protocols, then use automation and machine learning for single-cell dilution. Clones are screened with sequencing to ensure optimal clones are banked and delivered. 

Step 3 – Project delivered

Project updates are provided at regular intervals with validation and QC performed throughout prior to shipping the final clone and parental line alongside the full data pack. 

Project updates are provided at regular intervals with validation and QC performed throughout prior to shipping the final clone and parental line alongside the full data pack. 

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Please note that product labeling (such as kit insert, product label, and kit box) may be different compared to the company branding. Please contact your local representative for further details.