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HTRF Human Phospho-SLP76 (Tyr145) Detection Kit, Control Lysate

This cell lysate provides a way to validate the Phospho-SLP-76 (Tyr145) assay. As a positive control, it will enable researchers to avoid any detection issues when running the assay.

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Feature	Specification
Application	Cell Signaling

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This cell lysate provides a way to validate the Phospho-SLP-76 (Tyr145) assay. As a positive control, it will enable researchers to avoid any detection issues when running the assay.

View product information

Product variant

Part #:

64SLPY5TDA

List price

USD 500.00

Your price:

For research use only. Not for use in diagnostic procedures. All products to be used in accordance with applicable laws and regulations including without limitation, consumption, and disposal requirements under European REACH regulations (EC 1907/2006).

Product information

Overview

This HTRF cell-based assay enables rapid, quantitative detection of SLP-76 phosphorylated on Tyrosine 145. Phosphorylation of SLP-76 by ZAP-70 kinase creates a scaffold on which key signaling complexes are built in order to trigger T-lymphocyte activation. SLP-76 (Tyr145) is considered as a direct readout of ZAP-70 activation pathway in T-immune cells.

HTRF assays offer many advantages over other technologies:

Homogeneous add-and-read format
No wash steps
Low background
Straightforward miniaturization from 96- or 384-well microplates to high density assay formats such as 384-well low volume and 1536-well plates
Stable signal, providing flexibility in time of readout or size of assays

Specifications

Other specifications

Application	Cell Signaling
Automation Compatible	Yes
Brand	HTRF
Cellular or Signaling Pathway	T-cell receptor signaling
Detection Modality	HTRF
Lysis Buffer Compatibility	Lysis Buffer 2 Lysis Buffer 3 Lysis Buffer 4
Molecular Modification	Phosphorylation
Product Group	Control Lysate
Shipping Conditions	Shipped in Dry Ice
Target	SLP76
Target Class	Phosphoproteins
Target Species	Human
Technology	TR-FRET
Therapeutic Area	Adaptive Immunity
Unit Size	1 vial