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HTRF Human and Mouse Total NPM1, Control Lysate
HTRF Human and Mouse Total NPM1, Control Lysate
This lysate is a component of the Total NPM1 kit. It may be used as a positive control for NPM1 protein quantification.
| Feature | Specification |
|---|---|
| Application | Cell Signaling |
This lysate is a component of the Total NPM1 kit. It may be used as a positive control for NPM1 protein quantification.
HTRF Human and Mouse Total NPM1, Control Lysate
HTRF Human and Mouse Total NPM1, Control Lysate
Product information
Overview
NPM1 (Nucleophosmin 1) is a molecular chaperone involved in cell cycle regulation, ribosome biogenesis, cell proliferation, DNA damage repair, and apoptosis. Its phosphorylation on Thr199 by the CDK2/Cyclin E complex regulates mitosis, centrosome duplication, pre-mRNA processing, and G2/M cell cycle arrest through its interaction with p53/MDM2.
NPM1 functions both as an oncogene and a tumor suppressor. It is frequently overexpressed, altered, and rearranged, or sporadically deleted, in human cancers. NPM1 is also the most frequently mutated gene (NPM1c) in acute myeloid leukemia (AML).
Specifications
| Application |
Cell Signaling
|
|---|---|
| Automation Compatible |
Yes
|
| Brand |
HTRF
|
| Detection Modality |
HTRF
|
| Molecular Modification |
Total
|
| Product Group |
Control Lysate
|
| Shipping Conditions |
Shipped in Dry Ice
|
| Target |
NPM1
|
| Target Class |
Phosphoproteins
|
| Target Species |
Human
Mouse
|
| Technology |
TR-FRET
|
| Therapeutic Area |
Oncology
|
| Unit Size |
1 vial
|
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