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HTRF α-SMA Detection Kit, 500 Assay Points

The Alpha-SMA kit is designed for the accurate quantitative measurement of Alpha-Smooth Muscle Actin produced by cells.

For research use only. Not for use in diagnostic procedures. All products to be used in accordance with applicable laws and regulations including without limitation, consumption & disposal requirements under European REACH regulations (EC 1907/2006).
Part Number: 62ASMAPEG
Unit Size: 500 Assay Points
Part Number: 62ASMAPEH
Unit Size: 10,000 Assay Points
  • After tissue injury, TGF-beta locally released by inflammatory cells activates resident fibroblasts or quiescent HSCs (hepatic stellate cells). This leads to their differentiation into myofibroblasts, whose role is to migrate into the damaged tissue and synthesize ECM (extracellular matrix) components to repair the wound. Myofibroblasts are characterized by de novo expression of alpha-SMA, which is incorporated into actin stress fibers and confers a high contractile activity to the cells. Chronic tissue injury leads to persistent de novo formation of myofibroblasts (alpha-SMA+), excessive contraction, and deposition of ECM, eventually leading to tissue fibrosis.

  • Assay Points
    500
    Assay Target Type
    Kit
    Assay Technology
    HTRF
    Therapeutic Area
    Cardiovascular
    NASH/Fibrosis
    Brand
    HTRF
    Quantity
    1
    Unit Size
    500 Assay Points

Resources

1-1 of 1 Resources
Guide book
HTRF solutions, guide to major applications
HTRF, guide, application, autoimmunity, cardiology, assays