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The AlphaLISA® SureFire® Ultra™ Human Phospho-VAV1 (Tyr174) assay is a sandwich immunoassay for quantitative detection of phospho-VAV1 (Tyr174) in cellular lysates using Alpha Technology.
VAV1 is a Rho-family guanine nucleotide exchange factor that is encoded by a proto-oncogene, Vav Guanine Nucleotide Exchange factor 1. Wild-type VAV1 is recognized as a cardinal signal transducer protein in the hematopoietic system, where it is exclusively expressed. However, mutations in various domains of the VAV1 protein are present in human cancers, including T-cell leukemia/lymphoma, peripheral T-cell lymphomas, lung adenocarcinoma, and squamous cell carcinomas. VAV1 is also an activator of T and B cell receptor signaling, therefore making it a potential target for protein degradation therapies to combat autoimmune disease, such as multiple sclerosis.
The AlphaLISA SureFire Human Phospho-VAV1 (Tyr174) Detection Kit is a sandwich immunoassay for the quantitative detection of phospho-VAV1 (Tyr174) in cellular lysates, using Alpha Technology.
Protein Analysis & Detection
|Assay Target Class
AlphaLISA SureFire Ultra