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The AlphaLISA® SureFire® Ultra™ Human and Mouse Phospho-LRRK2 (Ser910) assay is a sandwich immunoassay for quantitative detection of phospho-LRRK2 (Ser910) in cellular lysates using Alpha Technology.
Leucine-rich repeat kinase 2, also known as LRRK2, Dardarin, or PARK8, is a member of the ROCO superfamily and is a large, multifunctional kinase enzyme. The ROCO family characteristics include the presence of a tandem Ras of complex (Roc) G-domain, kinase domains, and carboxy- terminal of Roc (COR) sequence which links them. LRRK2 modulates Tau phosphorylation via GSK-3b and is involved in lysosomal function and the innate immunity in the brain (microglia activation). Mutations observed in LRRK2 have been associated with Parkinson’s disease.
The AlphaLISA SureFire Human and Mouse Phospho-LRRK2 (Ser910) Detection Kit is a sandwich immunoassay for the quantitative detection of phospho-LRRK2 (Ser910) in cellular lysates, using Alpha Technology.
AlphaLISA SureFire Ultra