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Application Note

Imaging Hepatocellular Liver Injury using NIR-labeled Annexin V


Drug induced liver injury (DILI) is a major reason for late stage termination of drug discovery research projects, highlighting the importance of early integration of liver safety assessment in the drug development process. A technical approach for in vivo toxicology determination using IVISense® Annexin-V fluorescent probe and IVIS® SpectrumCT imaging system was developed to evaluate Acetaminophen (APAP), a commonly used over-the-counter analgesic and antipyretic drug, to induce acute hepatocellular liver injury.

For research use only. Not for use in diagnostic procedures. 

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Imaging Hepatocellular Liver Injury using NIR-labeled Annexin V

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