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Orexin A, [125I]-, 10µCi (370kBq)

Orexin A, labeled with 125I. Orexin A binds to orexin receptors (OX1 and OX2), which are potential drug targets for sleep disorders.

For research use only. Not for use in diagnostic procedures
Part Number: NEX367010UC
Unit Size: 10 µCi
Part Number: NEX367050UC
Unit Size: 50 µCi
  • 10 µCiQuantities of Orexin A, [125I]- are available for your research.

    We offer radioligands and radiolabeled biomolecules to use as tracers, for radioimmunoassays (RIAs), for autoradiographic visualization, or for performing saturation and competition radioligand binding assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radiolabeled compounds is fully characterized for pharmacological action and validated in binding assays.

    Radiochemicals remain the most sensitive method for probing binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, Revvity has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.

    References for NEX367:

    1. Wieland, H. A., Söll, R. M., Doods, H. N., Stenkamp, D., Hurnaus, R., Lämmle, B. and Beck-Sickinger, A. G. (2002), The SK-N-MC cell line expresses an orexin binding site different from recombinant orexin 1-type receptor. European Journal of Biochemistry, 269: 1128–1135.
  • Application
    Drug Discovery & Development
    Brand
    NEN Radiochemicals
    Detection Method
    Radiometric
    Fresh Lot Days
    Second Monday of each month
    Label Position
    Nominally Labeled
    Radionuclide
    125I
    Radioisotope
    I-125
    Receptor Type
    Orexin
    Shipping Conditions
    Shipped in Dry Ice
    Special Ordering Information
    This is a radioactive product - shipping address must have a license to receive radioactive materials.
    Therapeutic Area
    Gastrointestinal
    Metabolic Disorders
    Unit Size
    10 µCi

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