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Methylhistamine Dihydrochloride, N-α-[methyl-3H]-, 250µCi (9.25MBq)

(R)-α-methylhistamine dihydrochloride, tritiated on the methyl group. α-Methylhistamine is a histamine agonist selective for the histamine H3 receptor.

For research use only. Not for use in diagnostic procedures.

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YEAREND15
Offer valid until 12/15. Terms and conditions apply.
Feature Specification
Concentration 1 mCi/ml
Label Position Specifically Labeled
Molecular Weight 198
Receptor Histamine

(R)-α-methylhistamine dihydrochloride, tritiated on the methyl group. α-Methylhistamine is a histamine agonist selective for the histamine H3 receptor.

For research use only. Not for use in diagnostic procedures.

Click to copy promo code to clipboard.
SAVE 15% NOW on online orders. Use promo code below.
YEAREND15
Offer valid until 12/15. Terms and conditions apply.
Product Variant
Unit Size: 250 µCi
Part #:
NET1027250UC
List Price
USD 6,594.00

Overview

α-Methylhistamine is a selective agonist for the histamine H3 receptor. This receptor is a GPCR that is a potential drug target for central nervous system disorders.

We offer both agonist and antagonist radioligands for autoradiographic visualization or performing saturation and competition assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radioligands is fully characterized for pharmacological action and validated in receptor binding assays.

Radiolabeled ligands remain the most sensitive method for probing receptor binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, Revvity has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.

References for NET1027:

  1. Griebel, G., Pichat, P., Pruniaux, M., Beeské, S., Lopez-Grancha, M., Genet, E., Terranova, J.P., Castro, A., Sánchez, J.A., Black, M., Varty, G. B., Weiner, I., Arad, M., Barak, S., De Levie, A., Guillot, E. (2012), SAR110894, a potent histamine H3-receptor antagonist, displays procognitive effects in rodents, Pharmacology Biochemistry and Behavior, 102 (2): 203-214.
  2. Jin, C. Y., Kalimo, H. and Panula, P. (2002), The histaminergic system in human thalamus: correlation of innervation to receptor expression. European Journal of Neuroscience, 15: 1125–1138.

Specifications

Concentration
1 mCi/ml
Molecular Weight
198
Application
Drug Discovery & Development
Brand
NEN Radiochemicals
Buffer/Solvent
Ethanol : 0.01N hydrochloric acid (70:30)
Detection Modality
Radiometric
Label Position
Specifically Labeled
Packaging
NENSure vial
Radioisotope
3H
Receptor
Histamine
Shipping Conditions
Shipped in Dry Ice
Special Ordering Information
This is a radioactive product - shipping address must have a license to receive radioactive materials.
Storage Conditions
-20°C
Therapeutic Area
Inflammation
Unit Size
250 µCi

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