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IVISense Pan Cathepsin 680 Fluorescent Probe (ProSense 680)

Proteases perform a fundamental role in protein regulation. Altered activity of lysosomal cathepsins, a class of protease, can indicate many disease-related processes, such as those involved in cancer, inflammation, arthritis, cardiovascular and many others. The ability to detect and quantify normal as well as altered protease cathepsin activity in vivo allows the progress and severity of these disease states to be tracked and interrogated over time.

Revvity’s IVISense™ Pan Cathepsin fluorescent probes (ProSense®) are versatile pan-cathepsin-activatable NIR agents for imaging various disease-related events. These activatable probes are optically silent in their intact state and become highly fluorescent following protease-mediated cleavage and activation.

For research use only. Not for use in diagnostic procedures.

Product Variants
Part number: NEV10003
Wave Length: 680 nm
List price: USD 556.29
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USD 556.29
USD 556.29 /each
Part number: NEV10001EX
Wave Length: 750 nm
List price: USD 594.55
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USD 0.00
USD 594.55 /each
Part number: NEV11171
Style: FAST
Wave Length: 750 nm
List price: USD 656.59
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USD 0.00
USD 656.59 /each

Overview

IVISense Pan Cathepsin 680 is our original “Smart” cathepsin probe; rather than targeting all protease, smart probes become fluorescent only after enzymatic cleavage, which keeps background down and allows detection of activated protease. 24h imaging at 680 nm.

Specifications

Brand
IVISense
Fluorescent Agent Type
Activatable
Imaging Modality
Fluorescence
One Unit Contains
10.0 dose(s)
Shipping Conditions
Shipped in Blue Ice
Therapeutic Area
Arthritis
Atherosclerosis
Inflammation
Oncology/Cancer
Unit Size
1 Vial (10 doses)
Wave Length
680 nm

Resources

1-6 of 8 Resources
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Flyer
Best practices for designing an effective in vivo fluorescence imaging study

Fluorescence molecular imaging is the visualization of cellular and biological function in vivo to gain deeper insights into...

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eBook
In vivo imaging solutions

Researchers trust our in vivo imaging solutions to give them reliable, calibrated data that reveals pathway characterization and...

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Guide
IVISense fluorescent probe selector guide for oncology research

The goal of in vivo fluorescence molecular imaging is to enable non-invasive visualization and quantification of cellular and...

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Application Note
Multiplex 2D imaging of NIR molecular imaging agents on the IVIS SpectrumCT platform

Epifluorescence (2D) imaging of superficially implanted mouse tumor xenograft models offers a fast and simple method for assessing...

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Application Note
Noninvasive in vivo quantitation of asthma severity using IVISense fluorescent probes

This app note highlights using IVISense Pan Cathepsin 680 NIR fluorescent probe for noninvasive in vivo imaging and quantitation...

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Application Note
Quantitative analysis of 3D microtissue growth and biomarker intensity

SDS, COAs, Manuals and more

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Safety data sheet
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Technical data sheet
  • Lot number
    ANY
    Lot date
    September 6, 2023
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