AlphaLISA SureFire Ultra Human and Mouse Total WDR5 Detection Kit, 500 Assay Points

WD repeat-containing protein 5 (WDR5) is a member of the WD40 repeat domain protein family. WDR5 is a core scaffolding component of histone methyltransferase complexes. New data demonstrates that the protein is involved in additional processes, ranging from expanded functions in the nucleus to controlling the integrity of cell division. The canonical function of WDR5 is as a core component of the SET1/MLL histone methyltransferase complexes. WDR5 has emerged as a prime target for anti-cancer drug discovery efforts including the PROTAC degrader approach.

The AlphaLISA SureFire Human Total WDR5 Detection Kit is a sandwich immunoassay for the quantitative detection of total WDR5 in cellular lysates, using Alpha Technology.

Formats:

• The HV (high volume) kit contains reagents to run 100 wells in 96-well format, using a 60 μL reaction volume.
• The 500-point kit contains enough reagents to run 500 wells in 384-well format, using a 20 μL reaction volume.
• The 10,000-point kit contains enough reagents to run 10,000 wells in 384-well format, using a 20 μL reaction volume.
• The 50,000-point kit contains enough reagents to run 50,000 wells in 384-well format, using a 20 μL reaction volume.

AlphaLISA SureFire Ultra kits are compatible with:

• Cell and tissue lysates
• Antibody modulators
• Biotherapeutic antibodies

Alpha SureFire kits can be used for:

• Cellular kinase assays
• Receptor activation studies
• Screening