The AlphaLISA™ SureFire® Ultra™ Human and Mouse Total p27 KIP1 assay is a sandwich immunoassay for quantitative detection of total p27 KIP1 in cellular lysates using Alpha Technology.
For research use only. Not for use in diagnostic procedures. All products to be used in accordance with applicable laws and regulations including without limitation, consumption and disposal requirements under European REACH regulations (EC 1907/2006).
Cyclin-dependent kinase inhibitor 1B (p27 KIP1) is an enzyme inhibitor that is encoded by the CDKN1B gene. The p27 protein inhibits the activity of CDK2–cyclin E and CDK4–cyclin D complexes at the G1-phase and functions as a CDK-inhibitor that halts the S-phase transition. Mitogenic signals that decrease p27 expression allow CDK/cyclin activation and cell cycle progression. This protein participates in numerous signal transduction pathways and mediates tumor suppressor or oncogenic roles in cancers such as breast, colon, prostate, lung, esophageal, gastric, and ovarian.
The AlphaLISA SureFire Human and Mouse Total p27 KIP1 Detection Kit is a sandwich immunoassay for the quantitative detection of total p27 KIP1 in cellular lysates, using Alpha Technology.
Application |
Cell Signaling
|
---|---|
Assay Target |
p27 KIP1
|
Assay Target Class |
Phosphoproteins
|
Assay Technology |
Alpha
|
Automation Compatible |
Yes
|
Brand |
AlphaLISA SureFire Ultra
|
Detection Method |
Alpha
|
Molecular Modification |
Total
|
Product Group |
Kit
|
Sample Volume |
10 µL
|
Shipping Conditions |
Shipped in Blue Ice
|
Target Species |
Human
Mouse
|
Therapeutic Area |
Oncology
|
Unit Size |
500 Assay Points
|
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