The AlphaLISA™ SureFire® Ultra™ Mouse Total TDP-43 assay is a sandwich immunoassay for quantitative detection of total TDP-43 in cellular lysates using Alpha Technology.
For research use only. Not for use in diagnostic procedures. All products to be used in accordance with applicable laws and regulations including without limitation, consumption and disposal requirements under European REACH regulations (EC 1907/2006).
TAR DNA binding protein 43 (TDP-43) is a DNA and RNA-binding protein which plays a crucial role in RNA metabolism. Mainly located in the nucleus, TDP-43 shuttles between the nucleus and the cytoplasm. In pathological conditions, including stress or mutation, TDP-43 is mislocalized in the cytoplasm, which can be cleaved in C terminal fragments, thus leading to an accumulation of ubiquitinated and hyperphosphorylated toxic aggregates and then insoluble inclusion bodies. Aggregated TDP-43 has been identified as a hallmark of amyotrophic lateral sclerosis (ALS) and frontotemporal lobar dementia (FTLD), and more widely in several neurodegenerative diseases such as Alzheimer’s disease.
The AlphaLISA SureFire Mouse Total TDP-43 Detection Kit is a sandwich immunoassay for the quantitative detection of total TDP-43 in cellular lysates, using Alpha Technology.
Application |
Cell Signaling
|
---|---|
Automation Compatible |
Yes
|
Brand |
AlphaLISA SureFire Ultra
|
Detection Modality |
Alpha
|
Molecular Modification |
Total
|
Product Group |
Kit
|
Sample Volume |
10 µL
|
Shipping Conditions |
Shipped in Blue Ice
|
Target |
TDP-43
|
Target Class |
Phosphoproteins
|
Target Species |
Mouse
|
Technology |
Alpha
|
Therapeutic Area |
Neuroscience
|
Unit Size |
500 Assay Points
|
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