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The AlphaLISA® SureFire® Ultra™ Human and Mouse Total CREBBP assay is a sandwich immunoassay for quantitative detection of total CREBBP in cellular lysates using Alpha Technology.
The transcription coactivator CREB binding protein (CREBBP or CBP) is an acetyl transferase, that mediates histone 3 lysine 27 acetylation (H3K27ac) at regulatory elements such as enhancers and promoters. CREBBP/CBP inhibitors and degraders reduce H3K27ac, down-regulate oncogene transcription, induce cancer cell growth inhibition and cell death, activate immune response, overcome drug resistance and suppress tumor progression in vivo. CREBBP/CBP is over-expressed in cancer cells and in drug-resistant cancer cells, it activates oncogene transcription and induces cancer cell proliferation, survival, tumorigenesis, metastasis, immune evasion and drug-resistance.
The AlphaLISA SureFire Human and Mouse Total CREBBP Detection Kit is a sandwich immunoassay for the quantitative detection of total CREBBP in cellular lysates, using Alpha Technology.
Protein Analysis & Detection
|Assay Target Class
AlphaLISA SureFire Ultra