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The LabChip® GXII Touch™ protein characterization system provides the complete solution for reproducible quantitation, molecular weight sizing and percent purity analysis of protein samples. Leveraging microfluidic electrophoretic separation technology, the LabChip GXII Touch protein characterization system enables rapid characterization with minimal sample preparation setup and sample input volume.
The LabChip® GXII Touch™ protein characterization system offers an automated alternative to traditional methods by streamlining slab gel electrophoresis, while also providing the increased throughput and data quality required by biotherapeutics and genomics workflows. This flexible instrument supports multiple assays for characterizing both proteins and nucleic acids.
With the LabChip® GXII Touch™ protein characterization system, analysis can be performed in as few as 42 seconds per sample, delivering data comparable to data obtained using traditional capillary electrophoresis with as much as a 70X increase in throughput. With an easy-to-use touch screen interface, even novice users can run samples quickly.
Nucleic Acid Assays
User friendly operation
Observe runs in real time
See data in real time or export for later analysis
The LabChip GXII Touch protein characterization system operator controls are designed to allow users to easily set up and execute a run in as few as three easy steps (Figure 3). Run templates can also be imported with the operator control features. Run templates can include well selections, sample names, peak tables, which facilitate operator ease of use, and data can be automatically exported to network or LIMS directories for subsequent analysis. Every instrument comes with a full software package for data review, allowing analysis from current or archived data sets. LabChip GXII Touch and Reviewer Software contain built-in technical controls and features specifically designed to support FDA 21 CFR Part 11 regulations. These features include a shared user account database, access controls, device check, enforced sequencing of run steps, audit trails, record copying, record retention, system documentation, and electronic signature controls.
The LabChip GXII Touch protein characterization system offers rapid quantification and quality control throughout biotherapeutics and genomic workflows. For example, automating the characterization process allows multiple, critical quality attributes to be obtained significantly faster. Researchers can now screen for optimal protein characteristics earlier in the process and integrate Quality by Design initiatives into their biotherapeutics development workflow.
Figure 1. The LabChip GXII Touch protein characterization system interface offers real-time run data output and complete sample analysis.
Figure 2. Software complies with FDA 21CFR Part 11 regulations.
Figure 3. RNA Pico assay
Figure 4. Glycan Screening assay
Figure 5. Protein Charge Variant assay
Figure 6. Protein Clear HR™ assay for impurity analysis
LabChip electrophoresis is performed on a small, microfluidic chip. Prior to analysis, reagents are loaded into the individual wells of the chip. These wells are connected to tiny microchannels about the size of a human hair etched within the quartz microfluidic chip. When the chip is loaded into the LabChip GXII Touch protein characterization system, the chip’s wells interface with platinum electrodes that provide voltage and current control. The instrument moves the microtiter plate directly under the chip’s capillary ‘sipper’, and approximately 150 nL of sample is aspirated onto the chip. Sample staining and destaining are performed automatically on the instrument platform. Individual sample analytes are separated electrophoretically and the bands detected via laser induced fluorescence in the capillaries of the chip. Sizing and concentration for each band are determined using ladder and internal markers. Rinsing the sipper between samples minimizes cross contamination.
To assist in your compliance planning, LabChip GxP Security Software is available which allows the LabChip GXII Touch protein characterization system to run in an environment consistent with CFR21 Part 11 compliance and validation. This includes access security, data security and verification, and a complete set of audit logging functionality. Please contact your local representative for more information.
Analysis & Detection
LabChip GXII Touch HT Protein Characterization System