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LabChip GXII Touch HT Protein Characterization System

The LabChip® GXII Touch protein characterization system provides the complete solution for reproducible quantitation, molecular weight sizing and percent purity analysis of protein samples. Leveraging microfluidic electrophoretic separation technology, the LabChip GXII Touch protein characterization system enables rapid characterization with minimal sample preparation setup and sample input volume.

For research use only. Not for use in diagnostic procedures.
Part Number: CLS138160
  • Fast and reliable automated QC solutions for biotherapeutics

    The LabChip® GXII Touch protein characterization system offers an automated alternative to traditional methods by streamlining slab gel electrophoresis, while also providing the increased throughput and data quality required by biotherapeutics and genomics workflows. This flexible instrument supports multiple assays for characterizing both proteins and nucleic acids.

    With the LabChip® GXII Touch protein characterization system, analysis can be performed in as few as 42 seconds per sample, delivering data comparable to data obtained using traditional capillary electrophoresis with as much as a 70X increase in throughput. With an easy-to-use touch screen interface, even novice users can run samples quickly.

  • Protein Assays

    • AAV EMPTY FULL ANALYSIS
    • PICO PROTEIN ASSAY
    • PROTEIN LOW MOLECULAR WEIGHT ASSAY
    • EXTENDED RANGE N-GLYCAN ASSAY
    • GLYCAN PROFILING ASSAY
    • PROTEIN CHARGE VARIANT ASSAY
    • PROTEIN EXPRESS ASSAY
    • PROTEIN CLEAR ASSAY
    • PROTEINEXACT ASSAY

    Nucleic Acid Assays

    • DNA 1K ASSAY
    • DNA 5K ASSAY
    • DNA 12K ASSAY
    • DNA HIGH SENSITIVITY ASSAY
    • GENOMIC DNA ASSAY
    • NGS 3K ASSAY
    • STANDARD RNA ASSAY
    • PICO RNA ASSAY
    • SMALL RNA ASSAY
    LabChip GXII Touch Instrument Simplifies Sample Analysis

    User friendly operation

    • Load sample plate and chip
    • Select samples (up to 384 in a run)
    • Select assay type
    • Touch ‘Run’ to start
    • Automatically export data directly to your network or LIMS system

    Observe runs in real time

    • Sample analysis in as few as 42 seconds
    • View electropherogram in real time during data collection
    • Overlay collected data to compare sample profiles
    • Select from various run time analytical feature annotations

    See data in real time or export for later analysis

    • Choose “display” in E-gram, virtual gel, or data table format (Figure 1)
    • Pull multiple archived plates into data review or analytical comparisons
    • Apply data mining filter functions on key attributes
    • Highlight expected peaks
    • Track relevant user access and data history parameters with FDA 21 CFR Part 11 compatible software

    The LabChip GXII Touch protein characterization system operator controls are designed to allow users to easily set up and execute a run in as few as three easy steps (Figure 3). Run templates can also be imported with the operator control features. Run templates can include well selections, sample names, peak tables, which facilitate operator ease of use, and data can be automatically exported to network or LIMS directories for subsequent analysis. Every instrument comes with a full software package for data review, allowing analysis from current or archived data sets. LabChip GXII Touch and Reviewer Software contain built-in technical controls and features specifically designed to support FDA 21 CFR Part 11 regulations. These features include a shared user account database, access controls, device check, enforced sequencing of run steps, audit trails, record copying, record retention, system documentation, and electronic signature controls.

    The LabChip GXII Touch protein characterization system offers rapid quantification and quality control throughout biotherapeutics and genomic workflows. For example, automating the characterization process allows multiple, critical quality attributes to be obtained significantly faster. Researchers can now screen for optimal protein characteristics earlier in the process and integrate Quality by Design initiatives into their biotherapeutics development workflow.

    labchip gxii touch protein characterization system fig1

    Figure 1. The LabChip GXII Touch protein characterization system interface offers real-time run data output and complete sample analysis.

    labchip gxii touch protein characterization system fig2

    Figure 2. Software complies with FDA 21CFR Part 11 regulations.

    labchip gxii touch protein characterization system fig3

    Figure 3. RNA Pico assay

    labchip gxii touch protein characterization system fig4

    Figure 4. Glycan Screening assay

    labchip gxii touch protein characterization system fig5

    Figure 5. Protein Charge Variant assay

    labchip gxii touch protein characterization system fig6

    Figure 6. Protein Clear HR™ assay for impurity analysis

    LabChip Electrophoresis: How Does it Work?

    LabChip electrophoresis is performed on a small, microfluidic chip. Prior to analysis, reagents are loaded into the individual wells of the chip. These wells are connected to tiny microchannels about the size of a human hair etched within the quartz microfluidic chip. When the chip is loaded into the LabChip GXII Touch protein characterization system, the chip’s wells interface with platinum electrodes that provide voltage and current control. The instrument moves the microtiter plate directly under the chip’s capillary ‘sipper’, and approximately 150 nL of sample is aspirated onto the chip. Sample staining and destaining are performed automatically on the instrument platform. Individual sample analytes are separated electrophoretically and the bands detected via laser induced fluorescence in the capillaries of the chip. Sizing and concentration for each band are determined using ladder and internal markers. Rinsing the sipper between samples minimizes cross contamination.

    21CFR Part 11 Compatible Software is available with the LabChip GXII Touch protein characterization system

    To assist in your compliance planning, LabChip GxP Security Software is available which allows the LabChip GXII Touch protein characterization system to run in an environment consistent with CFR21 Part 11 compliance and validation. This includes access security, data security and verification, and a complete set of audit logging functionality. Please contact your local representative for more information.

  • Depth
    49.0 cm
    Width
    51.0 cm
    21CFR Compatible
    Yes
    Analytical Technique
    Analysis & Detection
    DNA/RNA Isolation
    Application
    DNA/RNA Quantitation
    Automation Compatible
    Yes
    Brand
    LabChip GXII
    Model Name
    LabChip GXII Touch HT Protein Characterization System
    Research Areas
    Translational Research
    • Sun, Y. et al. (2023) ‘Application of microfluidic chip electrophoresis for high-throughput nucleic acid fluorescence fragment analysis assays’, NAR Genomics and Bioinformatics, 5(1). doi:10.1093/nargab/lqad011.
    • Cao, J., Perez-Pinera, P., Lowenhaupt, K., Wu, M., Purcell, O., Fuente-Nunez, C. D., & Lu, T. K. (2018). Versatile and on-demand biologics co-production in yeast. Nature Communications, 9(1). doi:10.1038/s41467-017-02587-w.
    • Reardon, H. T., Herbst, R. A., Henry, C. L., Herbst, D. M., Ngo, N., Cisar, J. S., . . . O’Neill, G. P. (2019). Quantification of In Vivo Target Engagement Using Microfluidic Activity-Based Protein Profiling. SLAS TECHNOLOGY: Translating Life Sciences Innovation,247263031985230. doi:10.1177/2472630319852303
    • Regula, J. T., Imhof-Jung, S., Mølhøj, M., Benz, J., Ehler, A., Bujotzek, A., . . . Klein, C. (2018). Variable heavy–variable light domain and Fab-arm CrossMabs with charged residue exchanges to enforce correct light chain assembly. Protein Engineering, Design and Selection,31(7-8), 289-299. doi:10.1093/protein/gzy021.
    • Smith, M. T., Zhang, S., Adams, T., Dipaolo, B., & Dally, J. (2017). Establishment and validation of a microfluidic capillary gel electrophoresis platform method for purity analysis of therapeutic monoclonal antibodies. Electrophoresis,38(9-10), 1353-1365. doi:10.1002/elps.201600519
    • Smith, M. T., Zhang, S., Adams, T., Dipaolo, B., & Dally, J. (2017). Establishment and validation of a microfluidic capillary gel electrophoresis platform method for purity analysis of therapeutic monoclonal antibodies. Electrophoresis,38(9-10), 1353-1365. doi:10.1002/elps.201600519.
    • Weng, Y., Ishino, T., Sievers, A., Talukdar, S., Chabot, J. R., Tam, A., . . . Lin, L. (2018). Glyco-engineered Long Acting FGF21 Variant with Optimal Pharmaceutical and Pharmacokinetic Properties to Enable Weekly to Twice Monthly Subcutaneous Dosing. Scientific Reports, 8(1). doi:10.1038/s41598-018-22456-w.

Resources

1-6 of 12 Resources
Application Note Icon Image
Application Note
An evaluation of control analysis system performance between the LabChip GXII and SCIEX PA800 Plus system
Protein Clear™ HR assay, SCIEX® PA800 Plus, LabChip GXII, mAb analysis, monoclonal antibody analysis, SCIEX mAb analysis, SCIEX monoclonal antibody analysis
Product Note
Automated characterization of proteins and nucleic acids
Automated proteins and nucleic acid characterization, protein characterization, DNA characterization, RNA characterization, protein characterization for biotherapeutics, DNA characterization for biotherapeutics, RNA characterization for biotherapeutics
Application Note Icon Image
Application Note
Automated microfluidic capillary electrophoresis for measurement of full and empty adeno‑associated virus capsids.
AAV, AAV empty full, AAV empty/full, LabChip AAV, LabChip GXII Touch instrument
Application Note Icon Image
Application Note
Bioanalytical Evaluation Single-stranded DNA for Gene Therapy Applications App Note
ssDNA, single stranded DNA, AAV, ssDNA ladder, ssDNA size standard, LabChip GXII Touch instrument
Application Note Icon Image
Application Note
Characterization of NISTmAb with microfluidic CE-SDS
Characterization of NISTmAb, NISTmAb, NIST monoclonal antibody characterization, NIST monoclonal antibody, LabChip GXII, NISTmAb analysis, antibody characterization, monoclonal antibodies
Product Note
Choosing the right molecular-weight size marker matters Product Note
LabChip GXII Touch instrument, ssDNA, single stranded DNA, AAV, ssDNA size standard, ssDNA ladder