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Oxytocin, [Tyrosyl-3,5-3H]-, 50µCi (1.85MBq)

Oxytocin, tritiated on the tyrosyl group. Oxytocin is a neurotransmitter that binds and activates oxytocin receptors.

For research use only. Not for use in diagnostic procedures

Part number: NET858050UC
List price: USD 4,216.00
Your price:
USD 4,216.00
USD 4,216.00 /each

Overview

Oxytocin is the endogenous ligand for oxytocin receptors. These receptors are a family of GPCRs that are involved in uterine contractions, milk production, stress, anxiety, social memory and recognition, and bonding.

We offer both agonist and antagonist radioligands for autoradiographic visualization or performing saturation and competition assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radioligands is fully characterized for pharmacological action and validated in receptor binding assays.

Radiolabeled ligands remain the most sensitive method for probing receptor binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, Revvity has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.

References for NET858:

  1. Braida, D., Donzelli, A., Martucci, R. et al. Neurohypophyseal hormones manipulation modulate social and anxiety-related behavior in zebrafish. Psychopharmacology (2012) 220: 319.
  2. Gimpl, G., Fahrenholz, F. Cholesterol as stabilizer of the oxytocin receptor, In Biochimica et Biophysica Acta (BBA) - Biomembranes (2002) 1564 (2): 384-392.

Specifications

Molecular Weight
1007.23
Application
Drug Discovery & Development
Brand
NEN Radiochemicals
Detection Method
Radiometric
Label Position
Specifically Labeled
Radionuclide
3H
Radioisotope
H-3
Receptor Type
Oxytocin
Shipping Conditions
Shipped in Dry Ice
Special Ordering Information
This is a radioactive product - shipping address must have a license to receive radioactive materials.
Therapeutic Area
Gastrointestinal
Metabolic Disorders
Unit Size
50 µCi

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