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Methylspiperone, [N-Methyl-3H]-, 250µCi (9.25MBq)

Methylspiperone radioligand tritiated at the N-Methyl position. Methylspiperone is an antagonist at the 5-HT2A receptor and a selective dopamine D2 antagonist.

For research use only. Not for use in diagnostic procedures
Part number: NET856250UC
List price: USD 5,009.00
Your price:
USD 5,009.00
USD 5,009.00 /each

Overview

Methylspiperone functions as an antagonist for both the 5-HT2A serotonin receptor and D2/3 dopamine receptor. It shows low affinity for α1-adrenergic receptors. Methylspiperone can be used as a PET tracer used to image D2/3 and 5HT2A receptor densities.

We offer both agonist and antagonist radioligands for autoradiographic visualization or performing saturation and competition assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radioligands is fully characterized for pharmacological action and validated in receptor binding assays.

Radiolabeled ligands remain the most sensitive method for probing receptor binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, Revvity has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.

References for NET856:

  1. Nathalie Schmieg, Cristina Rocchi, Stefania Romeo, Roberto Maggiom Mark J. Millan, Clotilde Mannoury la Cour. Dysbindin-1 modifies signaling and cellular localization of recombinant, human D3 and D2 receports. Journal of Neurochemistry, Volume 136, Issue 5, March 2016, pages 1037-1051.
  2. Dhwanil A. Dalwadi, Seongcheol Kim, Shahnawaz M. Amdani, Zhenglan Chen, Ren-Qi Huang, John A. Schetz. Molecular mechanisms of serotonergice action of the HIV-1 antiretrovial efavirenze. Pharmacological Research, volume 10, August 2016, pages 10-24
  3. Sehyoun Yoon, Mi-Hyun Choi, Ja-Hyuan Baik. Wnt ligan binding to and regulation of dopamine D2 receptors. Dopamine Receptor Technologies. Neuromethods, vol 96,November 2014, pages 65-78

Specifications

Molecular Weight
409.5
Application
Drug Discovery & Development
Brand
NEN Radiochemicals
Detection Method
Radiometric
Label Position
Specifically Labeled
Radionuclide
3H
Radioisotope
H-3
Receptor Type
Dopamine
Shipping Conditions
Shipped in Dry Ice
Special Ordering Information
This is a radioactive product - shipping address must have a license to receive radioactive materials.
Therapeutic Area
CNS & Neurologic
Unit Size
250 µCi

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