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IVISense Arthritis Fluorescent Imaging Panel
IVISense Arthritis Fluorescent Imaging Panel
IVISense™ Arthritis Fluorescent Panel containing 6 probes targeting the molecular players in arthritis research. Image show IVISense Neutrophil Elastase 680 FAST fluorescent agent in collagen antibody-induced arthritis
Standard arthritis assessment in animal models relies on external measurements (paw volume, thickness, redness) that show disease progression but miss underlying biology. Arthritis involves inflammation, vascular changes, and bone morphology alterations. Our IVISense Arthritis fluorescent panel offers carefully selected probes to measure these individual changes, providing researchers with deeper insights into disease mechanisms and progression.
Standard arthritis assessment in animal models relies on external measurements (paw volume, thickness, redness) that show disease progression but miss underlying biology. Arthritis involves inflammation, vascular changes, and bone morphology alterations. Our IVISense Arthritis fluorescent panel offers carefully selected probes to measure these individual changes, providing researchers with deeper insights into disease mechanisms and progression.
Product variant
Unit Size: 1 kit containing 6 vials
Part #:
NEV20003
List price
USD 2,081.00
Your online price:
For research use only. Not for use in diagnostic procedures.
IVISense Arthritis Fluorescent Imaging Panel
IVISense™ Arthritis Fluorescent Panel containing 6 probes targeting the molecular players in arthritis research. Image show IVISense Neutrophil Elastase 680 FAST fluorescent agent in collagen antibody-induced arthritis
IVISense Arthritis Fluorescent Imaging Panel
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Product information
Overview
The biology of arthritis is complex, involving multiple cellular players, secreted factors, and processes that can lead to sever joint damage. Our fluorescent imaging probes targeting arthritis research allows in vivo imaging of the magnitude of inflammation, bone destruction, cartilage degradation, and vascular leak (edema) in a manner that non-invasively predicts the underlying histopathology of this disease.
The availability of probes at 680 nm and 750 nm wavelengths further offer the opportunity for multiplex imaging of appropriate probe combinations to maximize information gained from research animals.
Additional product information
IVISense Arthritis Fluorescent Imaging Panel includes the following six probes:
| Part Number | Fluorescent Probe | Biological Target |
|---|---|---|
| NEV10003 | IVISense Pan Cathepsin 680 (ProSense 680) | Pan-cathepsin activatable probe: Lysosomal marker of inflammatory cells |
| NEV10011EX | IVISense Vascular 750 (AngeioSense 750EX) | Vascular probe: Leaks into sites of edema |
| NEV10020EX | IVISense Osteo 680 (OsteoSense 680EX) | Bone turnover targeted probe: Detects areas of exposed hydroxyapatite |
| NEV10126 | IVISense MMP 680 (MMPSense 680) | Pan-MMP activatable probe: Secreted marker of inflammatory cells, bone/cartilage degradation |
| NEV11000 | IVISense Cat K 680 FAST | Cathepsin K activatable probe: Secreted marker of osteoclasts, bone degradation |
| NEV11098 | IVISense Cat B 750 FAST | Cathepsin B activatable probe: Lysosomal marker of inflammatory cells |
Specifications
| Brand |
IVISense
|
|---|---|
| Imaging Modality |
Fluorescence
|
| Shipping Conditions |
Shipped in Blue Ice
|
| Storage Conditions |
+2 to +8 °C
|
| Therapeutic Area |
Arthritis
|
| Unit Size |
1 kit containing 6 vials
|
Resources
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Application Brief
Characterization of NIR fluorophores for their potential in non-specific tissue accumulation
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