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IVISbrite Staphylococcus aureus Xen40 Bioluminescent Bacterial Strain

IVISbrite Staphylococcus aureus Xen40 bioluminescent pathogenic bacteria was derived from the parental strain UAMS-1. For in vitro or in vivo imaging applications, IVISbrite S. aureus-Xen40 possesses a stable copy of the Photorhabdus luminescens lux operon on the bacterial chromosome.

For research use only. Not for use in diagnostic procedures.

For research use only. Not for use in diagnostic procedures.
Part Number: 119244
  • Infectious disease is a perennially important area for both life science research and drug discovery. Some of the first applications of IVIS® imaging technology were in tracking infections and monitoring host responses, and these applications are still at the forefront of research. Our bioluminescent infectious disease light-producing microorganisms have been developed to mimic both acute and chronic standard infection protocols presently used by researchers.

    • Engineered Bacterium: Staphylococcus aureus - Xen40
    • Parental Strain: UAMS-1
    • In Vitro/Ex Vivo: Growth profiles, Catheter model
    • In Vivo: Biofilm

    Advantages of using bioluminescent light-producing microorganisms for drug discovery in vitro:

    • Rapid and readily amenable to high throughput screening, e.g., 96 or 384-well format
    • Sensitivity - subtle changes in cellular viability are rapidly detected
    • Inexpensive - no additional substrates needed for bacterial assays

    Advantages of using bioluminescent light-producing microorganisms for drug discovery in vivo:

    • Rapid identification of lead drug candidates
    • Real-time efficacy data
    • May help to decrease drug failure by allowing disease relapse to be monitored in the same animal
  • Brand
    IVISbrite
    Gram Positive Gram Negative
    Gram positive
    Imaging Modality
    Bioluminenscence
    Luciferase Classification
    Bacterial luciferase
    Optical Imaging Classification
    Bioluminescence Imaging
    Therapeutic Area
    Infectious Diseases

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eBook
In vivo imaging solutions
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