5-Hydroxytryptamine Binoxalate (Serotonin Binoxalate), labeled with C-14 at the 1-position. 5-Hydroxytryptamine is a neurotransmitter and is the endogenous ligand for serotonin receptors. NEC855 replaces product NEC225, which was labeled at the 2-position.
For research use only. Not for use in diagnostic procedures
250 µCi quantity of 5-Hydroxytryptamine (5-HT) which binds and activates 5-HT (serotonin) receptors. These receptors are a group of GPCR and ligand-gated ion channels found in the peripheral and central nervous system, and are involved in anxiety, appetite, cognition, learning, memory, mood, nausea, sleep, and thermoregulation.
We offer both agonist and antagonist radioligands for autoradiographic visualization or performing saturation and competition assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radioligands is fully characterized for pharmacological action and validated in receptor binding assays.
Radiolabeled ligands remain the most sensitive method for probing receptor binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, Revvity has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.
Brand |
NEN Radiochemicals
|
---|---|
Detection Method |
Radiometric
|
Label Position |
Specifically Labeled
|
Radioisotope |
C-14
|
Receptor Type |
5-Hydroxytryptamine
|
Special Ordering Information |
This is a radioactive product - shipping address must have a license to receive radioactive materials.
|
Therapeutic Area |
Cardiovascular
CNS & Neurologic
|
Unit Size |
250 µCi
|
This document contains general information designed to provide a basic understanding of radiation safety for Carbon-14. While we...
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