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Membrane Target Systems: hERG K+ Channel membrane preparation

Cell membranes prepared from cells stably-transfected with hERG K+ receptor, in HEK-293 cells.

Some of our receptors may be restricted for sale in specified countries. Please inquire. For research use only. Not for use in diagnostic procedures

Part number: RBHERGM400UA
List price: USD 1,482.00
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USD 1,482.00
USD 1,482.00 /each

Overview

Membrane Target Systems are quality assured frozen membranes from cells that express hERG K+ Channel recombinant or endogenous receptors.

We submit every batch of receptor to stringent quality control testing that includes saturation radioligand binding assay to determine receptor concentration (Bmax) and affinity (Kd). Competition binding assays are performed determine affinity (Ki) against known reference agonists and antagonists. GTPγS data is also provided for some of our Gi-coupled receptors.

Membranes are carefully prepared and ready for a variety of HTS applications, including radioligand binding (using either proximitymethods, such as FlashPlate, or classical filtration methods).

Products are packaged as frozen crude membrane preparations. One assay unit is defined as micrograms of protein, defined by competition binding assay (filtration). A complete product description and recommended protocol are included on the Product Information Sheet.

Some of our receptors may be restricted for sale in specified countries. Please inquire.

Specifications

Application
Drug Discovery & Development
Assay Validation
Binding
Assay Target Class
Ion channel
Brand
Membrane Target Systems
Host
HEK293
One Unit Contains
400.0 assays
Product Group
Membrane Preparation
Receptor Type
hERG
Shipping Conditions
Shipped in Dry Ice
Therapeutic Area
Cancer
Cardiovascular
Unit Size
400 units

Resources

SDS, COAs, Manuals and more

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