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AequoScreen Human Serotonin 5-HT2C (edited) Cell Line, CHO-K1 Cells
AequoScreen Human Serotonin 5-HT2C (edited) Cell Line, CHO-K1 Cells
Stable, recombinant AequoScreen® cell line expressing aequorin and the Serotonin receptor 5-HT2C, human recombinant in CHO-K1 host cells.
For research use only. Not for use in diagnostic procedures. Cell Line Terms and Conditions must be accepted before orders are placed. Additional agreement needed for commercial use. Click here.
| Feature | Specification |
|---|---|
| Application | Drug Discovery & Development |
| G-Alpha Coupling Protein | Gα16 |
| G-Alpha Natural Receptor | Gq/G11 |
| Special Ordering Information | Requires accepted Terms and Conditions. Additional agreement needed for commercial use. |
| Validation |
Binding Calcium Fluorescence Calcium Luminescence |
Stable, recombinant AequoScreen® cell line expressing aequorin and the Serotonin receptor 5-HT2C, human recombinant in CHO-K1 host cells.
For research use only. Not for use in diagnostic procedures. Cell Line Terms and Conditions must be accepted before orders are placed. Additional agreement needed for commercial use. Click here.
AequoScreen Human Serotonin 5-HT2C (edited) Cell Line, CHO-K1 Cells
AequoScreen Human Serotonin 5-HT2C (edited) Cell Line, CHO-K1 Cells
Product information
Overview
Revvity's AequoScreen double transfected cell lines are provided in two vials of frozen cells, each containing ∽2.5 x 106 cells. Detailed product information as well as recommended cell culture conditions and validation assay date are available each cell line.
AequoScreen technology is a generic GPCR technology that can be used with Gs, Gi, and Gq-coupled GPCRs and calcium coupled ion channels. Following receptor stimulation, increases in intracellular calcium enable measurement of resulting flash luminescence signal.
Features:
- Fully automatable and miniaturizable to 1536
- Enables reduction in reagents and consumable costs
- High signal to background ratio enabling detection of agonists, antagonists and allosteric modulators
- Robust assay (Z′, CV values, solvent resistance)
- Reduces number of false positives from autofluorescent compounds in screening libraries
- Option to work with cells in suspension to increase throughput
- Amenable use with calcium coupled ion channels and tyrosine kinase receptors
Revvity’s AequoScreen cell lines require accepted cell line Terms and Conditions prior to order processing. Additional agreement needed for commercial use. Please use link above to accept Terms and Conditions or to request an agreement for commercial use.
Specifications
| Application |
Drug Discovery & Development
|
|---|---|
| Brand |
AequoScreen
|
| G-Alpha Coupling Protein |
Gα16
|
| G-Alpha Natural Receptor |
Gq/G11
|
| Host Cell Line |
CHO-K1
|
| Host Species |
Human
|
| Product Group |
Cell Line
|
| Receptor |
5-Hydroxytryptamine (Serotonin)
|
| Second Messenger Release |
Calcium flux
|
| Shipping Conditions |
Shipped in Dry Ice
|
| Special Ordering Information |
Requires accepted Terms and Conditions. Additional agreement needed for commercial use.
|
| Target Class |
GPCR
|
| Therapeutic Area |
Cardiovascular
Central Nervous System
Gastrointestinal
Metabolic
|
| Unit Size |
5 million cells
|
| Validation |
Binding
Calcium Fluorescence
Calcium Luminescence
|
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