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Flunitrazepam, [Methyl-3H]-, 250µCi (9.25MBq)

Flunitrazepam (Rohypnol), tritiated on the methyl group. Flunitrazepam is a benzodiazepine and acts as an agonist at GABAA (γ-aminobutyric acid) receptors.

For research use only. Not for use in diagnostic procedures

Part number: NET567250UC
List price: USD 2,900.00
Your price:
USD 2,900.00
USD 2,900.00 /each

Overview

Flunitrazepam acts as an agonist at GABAA receptors. This receptor is an aionotropic receptor and ligand-gated ion channel. Flunitrazepam is used to treat severe insomnia and has also been used as an anesthetic.

We offer both agonist and antagonist radioligands for autoradiographic visualization or performing saturation and competition assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radioligands is fully characterized for pharmacological action and validated in receptor binding assays.

Radiolabeled ligands remain the most sensitive method for probing receptor binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, Revvity has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.

References for NET567:

  1. M. Rey, A.S. Veleiro, A.A. Ghini, M.S. Kruse, G. Burton, H. Coirini, Effect of synthetic steroids on GABAA receptor binding in rat brain, In Neuroscience, Volume 290, 2015, Pages 138-146.
  2. Mariana Rey, María Sol Kruse, Lautaro D. Alvarez, Alberto A. Ghini, Adriana S. Veleiro, Gerardo Burton, Héctor Coirini, Neuroprotective action of synthetic steroids with oxygen bridge. Activity on GABAA receptor, In Experimental Neurology, Volume 249, 2013, Pages 49-58.

Specifications

Molecular Weight
313.3
Application
Drug Discovery & Development
Brand
NEN Radiochemicals
Detection Method
Radiometric
Label Position
Specifically Labeled
Radionuclide
3H
Radioisotope
H-3
Receptor Type
Benzodiazepine
GABAA
Shipping Conditions
Shipped Ambient
Special Ordering Information
This is a radioactive product - shipping address must have a license to receive radioactive materials.
Therapeutic Area
CNS & Neurologic
Unit Size
250 µCi

Resources

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