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CGRP (human), [125I]-, 50µCi

Calcitonin gene-related peptide (CGRP), labeled with 125I. CGRP binds calcitonin receptors.

For research use only. Not for use in diagnostic procedures
Part Number: NEX354010UC
Unit Size: 10 µCi
Part Number: NEX354050UC
Unit Size: 50 µCi
  • 50 µCi Quantities of CGRP (human), [125I]- are available for your research.

    We offer radioligands and radiolabeled biomolecules to use as tracers, for radioimmunoassays (RIAs), for autoradiographic visualization, or for performing saturation and competition radioligand binding assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radiolabeled compounds is fully characterized for pharmacological action and validated in binding assays.

    Radiochemicals remain the most sensitive method for probing binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, Revvity has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.

    References for NEX354:

    1. Meens, M., Mattheij, N., van Loenen, P., Spijkers, L., Lemkens, P., Nelissen, J., Compeer, M., Alewijnse, A. and De Mey, J. (2012), G-protein βγ subunits in vasorelaxing and anti-endothelinergic effects of calcitonin gene-related peptide. British Journal of Pharmacology, 166: 297–308.
    2. Moore, E.L., Gingell, J.J., Kane, S.A., Hay, D.L., Salvatore, C.A. (2010), Mapping the CGRP receptor ligand binding domain: tryptophan-84 of RAMP1 is critical for agonist and antagonist binding. Biochem Biophys Res Commun, 394 (1): 141-145.
  • Concentration
    87.6 µCi/mL
    Molecular Weight
    3912
    Application
    Drug Discovery & Development
    Brand
    NEN Radiochemicals
    Detection Method
    Radiometric
    Fresh Lot Days
    Third Monday of each month
    Label Position
    Nominally Labeled
    Radionuclide
    125I
    Radioisotope
    I-125
    Receptor Type
    Calcitonin
    Species
    Human
    Shipping Conditions
    Shipped in Dry Ice
    Special Ordering Information
    This is a radioactive product - shipping address must have a license to receive radioactive materials.
    Therapeutic Area
    Diabetes
    Gastrointestinal
    Unit Size
    50 µCi

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